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胃肠道间质瘤中伊马替尼耐药长链非编码RNA的鉴定

Identification of imatinib-resistant long non-coding RNAs in gastrointestinal stromal tumors.

作者信息

Yan Jingyi, Chen Didi, Chen Xiaolei, Sun Xuecheng, Dong Qiantong, Du Zhou, Wang Tingting

机构信息

Department of Gastroenterology and General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

Department of Radiotherapy and Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

出版信息

Oncol Lett. 2019 Feb;17(2):2283-2295. doi: 10.3892/ol.2018.9821. Epub 2018 Dec 11.

DOI:10.3892/ol.2018.9821
PMID:30675294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6341907/
Abstract

Long non-coding RNAs (lncRNAs) are an abundant RNA species that belong to the competing endogenous RNA network, which serves a critical role in the development, diagnosis and progression of diseases. Using chip technology, the current study analyzed the expression of lncRNAs in paired normal gastric tissues, primary gastrointestinal stromal tumor (GIST) tissues and GIST tissues resistant to imatinib mesylate. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to predict potential tumorigenesis and drug resistance mechanisms. The hypoxia-inducible factor-1 pathway was identified as a putative mediator of drug resistance. To the best of our knowledge, the current study was the first to investigate the role of lncRNAs in imatinib mesylate-resistant GISTs and primary GISTs using chip technology. An association was revealed between lncRNA expression and imatinib mesylate resistance. In summary, the current study identified a panel of dysregulated lncRNAs that may serve as potential biomarkers or drug targets for GISTs, particularly secondary imatinib-resistant GISTs.

摘要

长链非编码RNA（lncRNAs）是一种丰富的RNA种类，属于竞争性内源性RNA网络，在疾病的发生、诊断和进展中起关键作用。本研究利用芯片技术分析了lncRNAs在配对的正常胃组织、原发性胃肠道间质瘤（GIST）组织和对甲磺酸伊马替尼耐药的GIST组织中的表达情况。采用基因本体富集分析和京都基因与基因组百科全书通路分析来预测潜在的肿瘤发生和耐药机制。缺氧诱导因子-1通路被确定为耐药的一个假定介导因子。据我们所知，本研究是首次利用芯片技术研究lncRNAs在对甲磺酸伊马替尼耐药的GIST和原发性GIST中的作用。lncRNA表达与甲磺酸伊马替尼耐药之间存在关联。总之，本研究鉴定出一组失调的lncRNAs，它们可能作为GIST尤其是继发性甲磺酸伊马替尼耐药GIST的潜在生物标志物或药物靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/e6b6ddb944a0/ol-17-02-2283-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/6429f4af3b49/ol-17-02-2283-g00.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/dce7d41f6b3f/ol-17-02-2283-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/e6089fab1f6f/ol-17-02-2283-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/af7e5b68056c/ol-17-02-2283-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/12061b112a0c/ol-17-02-2283-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/27a4674067af/ol-17-02-2283-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/91a4bc238711/ol-17-02-2283-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/e14c8ae0959e/ol-17-02-2283-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/e6b6ddb944a0/ol-17-02-2283-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/6429f4af3b49/ol-17-02-2283-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/1ec3cce9ec70/ol-17-02-2283-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/dce7d41f6b3f/ol-17-02-2283-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/e6089fab1f6f/ol-17-02-2283-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/af7e5b68056c/ol-17-02-2283-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/12061b112a0c/ol-17-02-2283-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/27a4674067af/ol-17-02-2283-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/91a4bc238711/ol-17-02-2283-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/e14c8ae0959e/ol-17-02-2283-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a027/6341907/e6b6ddb944a0/ol-17-02-2283-g09.jpg

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