优化慢性肾脏病临床试验设计的行动计划
Action plan for optimizing the design of clinical trials in chronic kidney disease.
作者信息
Perkovic Vlado, Craig Jonathan C, Chailimpamontree Worawon, Fox Caroline S, Garcia-Garcia Guillermo, Benghanem Gharbi Mohammed, Jardine Meg J, Okpechi Ikechi G, Pannu Neesh, Stengel Benedicte, Tuttle Katherine R, Uhlig Katrin, Levey Andrew S
机构信息
The George Institute for Global Health, University of New South Wales Sydney, New South Wales, Australia.
Department of Nephrology, School of Public Health, University of Sydney, Sydney, New South Wales, Australia.
出版信息
Kidney Int Suppl (2011). 2017 Oct;7(2):138-144. doi: 10.1016/j.kisu.2017.07.009. Epub 2017 Sep 20.
Abstract
High-quality clinical trials are the cornerstone of evidence-based prevention and treatment of a disease, but nephrology has a strikingly weak base of such trials. Building the evidence base to improve outcomes for people with a kidney disease, therefore, requires both greater quantity and quality of clinical trials. To address these issues, we propose that we aim to enroll 30% of people with chronic kidney disease in trials by 2030. Goal 1: Strongly encourage and promote the conduct of clinical trials in people with chronic kidney disease to increase the number of clinical trials conducted. Goal 2: Optimize the design of clinical trials in people with chronic kidney disease. Goal 3: Increase the capacity for conducting clinical trials in people with chronic kidney disease.
摘要
高质量的临床试验是疾病循证预防和治疗的基石，但肾脏病学领域此类试验的基础极为薄弱。因此，要建立证据基础以改善肾病患者的治疗效果，就需要增加临床试验的数量并提高其质量。为解决这些问题，我们提议，到2030年，力争使30%的慢性肾病患者参与临床试验。目标1：大力鼓励并推动针对慢性肾病患者开展临床试验，以增加所进行的临床试验数量。目标2：优化针对慢性肾病患者的临床试验设计。目标3：提高针对慢性肾病患者开展临床试验的能力。
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