Xu Yuejia, Park Yeonhwa
Department of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Prev Nutr Food Sci. 2018 Dec;23(4):275-281. doi: 10.3746/pnf.2018.23.4.275. Epub 2018 Dec 31.
is a versatile model organism that has been applied to research involving obesity, aging, and neurodegenerative diseases. has many advantages over traditional animal models, including ease of handling, a short lifespan, a fully sequenced genome, ease of genetic manipulation, and a high similarity to human disease-related genes. With established models of human disease, provides a great platform for studying disease pathologies, including endoplasmic reticulum (ER) stress, which is characterized by the accumulation of unfolded and misfolded proteins involved in the pathologies of many diseases. ER stress can lead to activation of the unfolded and misfolded protein response, a mechanism that attenuates ER stress and recovers ER homeostasis. The current review gives an introduction to and ER stress, along with the pathological role of ER stress in disease and the application of worm models in ER stress-related research.
是一种通用的模式生物，已应用于涉及肥胖、衰老和神经退行性疾病的研究。与传统动物模型相比有许多优势，包括易于操作、寿命短、基因组已完全测序、易于进行基因操作以及与人类疾病相关基因高度相似。凭借已建立的人类疾病模型，为研究疾病病理提供了一个很好的平台，包括内质网（ER）应激，其特征是参与多种疾病病理的未折叠和错误折叠蛋白质的积累。内质网应激可导致未折叠和错误折叠蛋白反应的激活，这是一种减轻内质网应激并恢复内质网稳态的机制。本综述介绍了以及内质网应激，内质网应激在疾病中的病理作用以及蠕虫模型在内质网应激相关研究中的应用。
