Rassam Fadi, Cieslak Kasia P, Beuers Ulrich H W, van Gulik Thomas M, Bennink Roel J
Departments of Surgery.
Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Nucl Med Commun. 2019 Apr;40(4):388-392. doi: 10.1097/MNM.0000000000000979.
Technetium-99m (Tc) mebrofenin hepatobiliary scintigraphy (HBS) enables a quantitative assessment of liver function. This is normally performed in a fasting state and might therefore reflect the resting liver function. We evaluated the change in liver function using HBS after stimulation with an oral metabolic challenge. Healthy volunteers aged 50-60 (n=12) or older than or equal to 75 (n=12) years underwent two sequential HBS. The first scan was performed after an overnight fast and the second scan was performed after the administration of chocolate milk. Hepatic Tc-mebrofenin uptake rate (cMUR) was calculated and the difference was expressed as percentage. cMUR after fasting was 10.9±2.5%/min/m (mean±SD) and increased by 20% to 13.0±3.1%/min/m after stimulation with chocolate milk (P<0.001). cMUR increased markedly after the administration of an oral metabolic challenge in comparison with fasting. This may be a consequence of hepatocyte stimulation, reflecting the hepatic functional reserve capacity.
锝-99m（Tc）美布芬宁肝胆闪烁显像（HBS）可对肝功能进行定量评估。这通常在禁食状态下进行，因此可能反映静息肝功能。我们使用口服代谢激发试验后通过HBS评估肝功能的变化。50 - 60岁（n = 12）或75岁及以上（n = 12）的健康志愿者接受了两次连续的HBS检查。第一次扫描在禁食过夜后进行，第二次扫描在给予巧克力牛奶后进行。计算肝脏Tc - 美布芬宁摄取率（cMUR），差异以百分比表示。禁食后cMUR为10.9±2.5%/min/m（平均值±标准差），在用巧克力牛奶激发后增加20%至13.0±3.1%/min/m（P < 0.001）。与禁食相比，口服代谢激发试验后cMUR显著增加。这可能是肝细胞受刺激的结果，反映了肝脏功能储备能力。
