Department of Chemistry , Kansas State University , 213 CBC Building, 1212 Mid-Campus Drive North , Manhattan , Kansas 66506 , United States.
Department of Applied Chemistry, Graduate School of Engineering , Osaka University , 2-1 Yamadaoka, Suita , Osaka 565-0871 , Japan.
Bioconjug Chem. 2019 Mar 20;30(3):861-870. doi: 10.1021/acs.bioconjchem.9b00006. Epub 2019 Feb 6.
Curcumin (Cur) has a wide range of bioactivities that show potential for the treatment of cancer as well as chronic diseases associated with inflammation and aging. However, the therapeutic efficacy of Cur has been hampered by its rapid degradation under physiological conditions and low aqueous solubility. To address these problems, we prepared Cur-loaded polymeric nanoparticles (CNPs), in which Cur was complexed with phenylboronic acid-containing framboidal nanoparticles (NPs), by simple mixing of Cur and NPs in an aqueous solution. CNPs showed improved chemical stability of Cur and released it in a sustained manner under physiological conditions. Furthermore, CNPs significantly enhanced the antiangiogenic and anticancer activities of Cur in chicken chorioallantoic membrane models.
姜黄素（Cur）具有广泛的生物活性，显示出治疗癌症以及与炎症和衰老相关的慢性疾病的潜力。然而，Cur 的治疗功效受到其在生理条件下快速降解和低水溶解度的限制。为了解决这些问题，我们通过在水溶液中简单混合 Cur 和 NPs，制备了负载姜黄素的聚合物纳米颗粒（CNPs），其中 Cur 与含苯硼酸的准晶纳米颗粒（NPs）形成复合物。CNPs 提高了 Cur 的化学稳定性，并在生理条件下以持续的方式释放 Cur。此外，CNPs 显著增强了 Cur 在鸡胚绒毛尿囊膜模型中的抗血管生成和抗癌活性。
