Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran.
Medicinal Plant Breeding and Development Research Institute, University of Kurdistan, Sanandaj 66177-15175, Iran.
Molecules. 2022 Aug 16;27(16):5236. doi: 10.3390/molecules27165236.
Throughout the United States, cancer remains the second leading cause of death. Traditional treatments induce significant medical toxic effects and unpleasant adverse reactions, making them inappropriate for long-term use. Consequently, anticancer-drug resistance and relapse are frequent in certain situations. Thus, there is an urgent necessity to find effective antitumor medications that are specific and have few adverse consequences. Curcumin is a polyphenol derivative found in the turmeric plant ( L.), and provides chemopreventive, antitumor, chemo-, and radio-sensitizing properties. In this paper, we summarize the new nano-based formulations of polyphenolic curcumin because of the growing interest in its application against cancers and tumors. According to recent studies, the use of nanoparticles can overcome the hydrophobic nature of curcumin, as well as improving its stability and cellular bioavailability in vitro and in vivo. Several strategies for nanocurcumin production have been developed, each with its own set of advantages and unique features. Because the majority of the curcumin-based nanoformulation evidence is still in the conceptual stage, there are still numerous issues impeding the provision of nanocurcumin as a possible therapeutic option. To support the science, further work is necessary to develop curcumin as a viable anti-cancer adjuvant. In this review, we cover the various curcumin nanoformulations and nanocurcumin implications for therapeutic uses for cancer, as well as the current state of clinical studies and patents. We further address the knowledge gaps and future research orientations required to develop curcumin as a feasible treatment candidate.
在美国，癌症仍然是导致死亡的第二大原因。传统的治疗方法会引起明显的医疗毒性作用和不良反应，因此不适合长期使用。在某些情况下，癌症药物耐药性和复发很常见。因此，迫切需要寻找有效、特异、不良反应少的抗肿瘤药物。姜黄素是姜黄植物（ L.）中的一种多酚衍生物，具有化学预防、抗肿瘤、化疗和放射增敏作用。本文总结了多酚姜黄素的新型纳米制剂，因为人们对其在癌症和肿瘤治疗中的应用越来越感兴趣。根据最近的研究，纳米粒子的使用可以克服姜黄素的疏水性，提高其在体外和体内的稳定性和细胞生物利用度。已经开发出几种纳米姜黄素的生产策略，每种策略都有其自身的优势和独特的特点。由于基于姜黄素的纳米制剂的大部分证据仍处于概念阶段，仍然存在许多问题阻碍了纳米姜黄素作为一种可能的治疗选择的提供。为了支持科学，需要进一步研究将姜黄素开发为一种可行的抗癌佐剂。在这篇综述中，我们介绍了各种姜黄素纳米制剂和纳米姜黄素在癌症治疗中的应用，以及目前的临床研究和专利状况。我们进一步讨论了开发姜黄素作为可行治疗候选药物所需的知识空白和未来研究方向。
