Vaiserman Alexander, Koliada Alexander, Zayachkivska Alina, Lushchak Oleh
Laboratory of Epigenetics, D.F. Chebotarev Institute of Gerontology, NAMS, Kyiv, Ukraine.
Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.
Front Bioeng Biotechnol. 2020 Jan 10;7:447. doi: 10.3389/fbioe.2019.00447. eCollection 2019.
The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.
衰老过程与氧化应激加剧及相关的全身炎症有关。因此，补充抗氧化剂被视为对抗衰老及相关病理状况的一种有前景的策略。来自植物提取物的食品级抗氧化剂是这些补充剂中最常见的成分。姜黄素、白藜芦醇、儿茶素、槲皮素等植物生物活性化合物是最常用的天然化合物，用作自由基诱导的细胞损伤的潜在调节剂。然而，这些化合物的治疗潜力受到其低生物利用度的限制，这与它们在胃肠道中的低溶解度、稳定性和吸收率有关。最近，基于纳米技术的新型系统被开发用于天然抗氧化剂的治疗性递送，从而提高生物利用度，并因此提高临床实践中的疗效。与传统制剂相比，此类系统在临床前研究中已带来诸多益处，包括更高的溶解度和稳定性、更长的半衰期、改善的上皮通透性和生物利用度、增强的组织靶向性以及最小化的副作用。本综述总结了天然抗氧化剂纳米递送的最新进展及其在对抗与氧化应激相关的病理状况中的应用。
