a Department of Mechanical Engineering , K. N. Toosi University of Technology , Tehran , Iran.
b Joint Department of Biomedical Engineering , University of North Carolina and North Carolina State University , Raleigh , NC , USA.
Expert Opin Drug Discov. 2019 Feb;14(2):101-113. doi: 10.1080/17460441.2019.1567489. Epub 2019 Jan 24.
Inkjet-dispensing printing is a promising additive manufacturing method for pharmaceutical applications such as drug discovery. The unique advantages of this technology, including low cost, programmability, high resolution, high throughput, high speed, and biocompatibility, may reduce the financial resources needed to discover new drug candidates. Sophisticated and miniaturized assays have been developed to accomplish drug discovery and drug screening using modern inkjet dispensing printers. Areas covered: This paper reviews recent advancements in the field of inkjet printer technology for drug discovery. Various types of inkjet printers and their recent use for the drug discovery are summarized; physical and biological limitations of this technology are also examined. Furthermore, typical inks used in the inkjet printing technology are introduced. Expert opinion: Inkjet bioprinting technology is a promising tool for many biological and pharmaceutical applications. Several bottlenecks associated with this technology need to be addressed before commercialization. For example, sophisticated inks need to be synthesized to meet both biological and engineering restrictions. Further progress of parallel technologies will enhance the performance and functionality of the printers. It is also worth emphasizing that inkjet printing technologies must meet the requirement of regulatory agencies (e.g. the US Food & Drug Administration) for commercialization by the pharmaceutical industry.
喷墨分配打印是一种有前途的药物发现等药物应用的添加剂制造方法。该技术的独特优势,包括低成本、可编程性、高分辨率、高通量、高速和生物相容性,可能会降低发现新候选药物所需的财务资源。已经开发出复杂和微型化的测定方法,以使用现代喷墨分配打印机完成药物发现和药物筛选。涵盖领域:本文综述了喷墨打印机技术在药物发现领域的最新进展。总结了各种类型的喷墨打印机及其最近在药物发现中的应用;还检查了该技术的物理和生物学限制。此外,还介绍了喷墨打印技术中使用的典型油墨。专家意见:喷墨生物打印技术是许多生物和制药应用的有前途的工具。在商业化之前,需要解决与该技术相关的几个瓶颈问题。例如,需要合成复杂的油墨以满足生物学和工程学的限制。并行技术的进一步进展将提高打印机的性能和功能。还值得强调的是,喷墨打印技术必须满足监管机构(例如美国食品和药物管理局)的要求,才能由制药行业商业化。