Department of Agri-Food Science and Technology (DISTAL), University of Bologna, Piazza Goidanich 60, 47521 Cesena, Italy.
Discipline of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Nutrients. 2017 Aug 30;9(9):958. doi: 10.3390/nu9090958.
Fruits rich in polyphenols, such as pomegranates, have been shown to have health benefits relating to their antioxidant and anti-inflammatory properties. Using data obtained from PubMed and Scopus, this article provides a brief overview of the therapeutic effects of pomegranate on chronic inflammatory diseases (CID) such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), metabolic and cardiovascular disorders, and other inflammatory-associated conditions, with an emphasis on fruit-derived juices. Most studies regarding the effects of pomegranate juice have focused on its ability to treat prostate cancer, diabetes, and atherosclerosis. However, pomegranate juice has shown therapeutic potential for many other illnesses. For instance, a small number of human clinical trials have highlighted the positive effects of pomegranate juice and extract consumption on cardiovascular health. The beneficial effects of pomegranate components have also been observed in animal models for respiratory diseases, RA, neurodegenerative disease, and hyperlipidaemia. Furthermore, there exists strong evidence from rodent models suggesting that pomegranate juice can be used to effectively treat IBD, and as an anti-inflammatory agent to treat CID. The effects of pomegranate intake should be further investigated by conducting larger and more well-defined human trials.
富含多酚的水果，如石榴，已被证明具有与其抗氧化和抗炎特性相关的健康益处。本文使用从 PubMed 和 Scopus 获得的数据，简要概述了石榴对慢性炎症性疾病（CID）的治疗作用，如炎症性肠病（IBD）、类风湿性关节炎（RA）、代谢和心血管疾病以及其他与炎症相关的疾病，并重点介绍了源自水果的果汁。大多数关于石榴汁作用的研究都集中在其治疗前列腺癌、糖尿病和动脉粥样硬化的能力上。然而，石榴汁对许多其他疾病也显示出治疗潜力。例如，少数人体临床试验强调了石榴汁和提取物对心血管健康的积极影响。在呼吸道疾病、RA、神经退行性疾病和高脂血症的动物模型中也观察到了石榴成分的有益作用。此外，啮齿动物模型提供了强有力的证据表明，石榴汁可有效治疗 IBD，并作为抗炎剂治疗 CID。应该通过进行更大、更明确的人体试验来进一步研究石榴摄入的效果。
