Yeragani V K, Pohl R, Balon R, Rainey J M, Berchou R, Ortiz A
Lafayette Clinic, Detroit, MI 48207.
Biol Psychiatry. 1988 Nov;24(7):767-74. doi: 10.1016/0006-3223(88)90252-1.
Fourteen patients with panic disorder were infused with sodium lactate both before and after treatment with tricyclic antidepressants. All patients had panic attacks before treatment, and only five after treatment. There was a significant decrease in measures of anxiety prior to and during infusions after treatment. The patients were able to tolerate more lactate during reinfusions. The comparison of reinfusion panickers and nonpanickers revealed that the reinfusion panickers had higher levels of anxiety, as measured by psychological symptoms on the Panic Description Scale, during both their pretreatment and posttreatment infusions. Tricyclic antidepressants appear to increase the threshold for lactate-induced panic attacks.
14名惊恐障碍患者在接受三环类抗抑郁药治疗前后均输注了乳酸钠。所有患者在治疗前均有惊恐发作，治疗后只有5人发作。治疗后输注前及输注过程中焦虑指标显著下降。患者在再次输注时能够耐受更多的乳酸。再次输注时惊恐发作患者与未发作患者的比较显示，再次输注时惊恐发作患者在治疗前和治疗后的输注过程中，根据惊恐描述量表上的心理症状测量，焦虑水平更高。三环类抗抑郁药似乎提高了乳酸诱发惊恐发作的阈值。
