Yeragani V K, Balon R, Rainey J M, Ortiz A, Berchou R, Lycaki H, Pohl R
Outpatient Department, Lafayette Clinic, Detroit, MI 48207.
Psychiatry Res. 1988 Feb;23(2):161-6. doi: 10.1016/0165-1781(88)90006-6.
The effects of infusion-induced panic-anxiety on subsequent pre-infusion anxiety ratings and infusion-induced panic attacks were studied in 64 panic disorder patients, in a double-blind randomized study using sodium lactate, isoproterenol, and placebo infusions. While there was a decrease of preinfusion anxiety from one infusion to the next infusion both for panickers and nonpanickers, there was no evidence of either a significant decrease or an increase in the frequency of subsequent panic attacks. These results suggest that there is neither a desensitizing nor a sensitizing effect of pharmacologically induced panic attacks on subsequent infusions in a serial three-infusion design.
在一项双盲随机研究中，对64名惊恐障碍患者使用乳酸钠、异丙肾上腺素和安慰剂输注，研究输注诱发的惊恐 - 焦虑对后续输注前焦虑评分和输注诱发的惊恐发作的影响。虽然惊恐者和非惊恐者从一次输注到下一次输注时输注前焦虑都有所降低，但没有证据表明后续惊恐发作的频率有显著降低或增加。这些结果表明，在连续三次输注设计中，药理学诱导的惊恐发作对后续输注既没有脱敏作用也没有致敏作用。
