Nissen C
Department of Research, University Hospital Basel, Switzerland.
Blood Cells. 1988;14(2-3):521-31.
There are two distinct hemopoietic activities in human serum that do not have the properties of the known hemopoietic lymphokines. These two activities appear not to be produced by immune competent cells. "Direct" stimulatory activity acts in primary target cultures of normal marrow. There does not appear to be a feedback mechanism between bone marrow failure and "direct" activity; it appears to reflect ongoing disease. Indirect "releaser" activity stimulates peripheral blood cells to produce hemopoietic growth factors. It is invariably elevated when release of hemopoietic growth factors is poor, indicating that a feedback mechanism exists. The peripheral blood cells of young patients, particularly young girls, respond poorly to autologous "releaser" stimulation. Results of treatment with ALG in this group are poor. However, all patients with aplastic anemia appear capable of producing adequate amounts "releaser" factor.
人血清中有两种不同的造血活性，它们不具备已知造血淋巴因子的特性。这两种活性似乎不是由免疫活性细胞产生的。“直接”刺激活性作用于正常骨髓的原代靶细胞培养物。骨髓衰竭与“直接”活性之间似乎不存在反馈机制；它似乎反映了正在发生的疾病。间接“释放”活性刺激外周血细胞产生造血生长因子。当造血生长因子释放不佳时，它总是升高，表明存在反馈机制。年轻患者，尤其是年轻女孩的外周血细胞对自体“释放”刺激反应较差。该组患者接受抗淋巴细胞球蛋白（ALG）治疗的效果不佳。然而，所有再生障碍性贫血患者似乎都能够产生足够量的“释放”因子。
