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用于老年急性呼吸困难患者早期分诊的肺部超声评分

A lung ultrasound score for early triage of elderly patients with acute dyspnea.

作者信息

Markarian Thibaut, Zieleskiewicz Laurent, Perrin Gilles, Claret Pierre-Géraud, Loundou Anderson, Michelet Pierre, Bobbia Xavier

机构信息

*Department of Emergency Medicine and Intensive Care,Timone University Hospital,Marseille,France.

†Department of Anesthesiology and Intensive Care,North Hospital,APHM,Aix-Marseille University,Marseille,France.

出版信息

CJEM. 2019 May;21(3):399-405. doi: 10.1017/cem.2018.483. Epub 2019 Jan 25.

Abstract

OBJECTIVES

Lung ultrasound has value in diagnosing dyspnea. The main objective of this study was to evaluate the accuracy of a modified lung ultrasound (MLUS) score to predict the severity of acute dyspnea in elderly patients.

METHODS

This was an observational single-centre study including patients over age 64 admitted to the emergency department for acute dyspnea with hypoxia. Participants had an early lung ultrasound performed by a dedicated emergency physician, followed by the usual care by a team blinded to the lung ultrasound results. Patients were allocated by disposition to either a critical care (CC) group (patients who needed admission to the intensive care unit [ICU] and/or who died within 48 h) or a standard care group.

RESULTS

Among 137 patients analysed (mean age 79 ± 13 years, 74 [54%] women), 43 (31%) were categorized into the CC group. The time taken to obtain the MLUS was 30 ± 22 min. The area under the receiver operating characteristic curve of the MLUS for predicting the CC group was 0.97 (0.92-0.99; p < 0.01) with a cut-off set strictly above 17 for 93% sensitivity (81-99), 99% specificity (94-100), a positive predictive value of 98% (87-100), a negative predictive value of 97% (91-99), a positive likelihood ratio of 86, a negative likelihood ratio of 0.07, and a diagnostic accuracy of 97% (93-99). In a multivariate analysis, the MLUS was the only independent associated factor for the CC group.

CONCLUSION

An early lung ultrasound score can predict the need for ICU admission and/or death within 48 hours in elderly dyspneic patients.

摘要

目的

肺部超声在诊断呼吸困难方面具有价值。本研究的主要目的是评估改良肺部超声(MLUS)评分预测老年患者急性呼吸困难严重程度的准确性。

方法

这是一项单中心观察性研究,纳入了因急性呼吸困难伴低氧血症而入住急诊科的64岁以上患者。参与者由一名专门的急诊科医生进行早期肺部超声检查,随后由对肺部超声结果不知情的团队进行常规护理。患者根据处置情况被分配到重症监护(CC)组(需要入住重症监护病房[ICU]和/或在48小时内死亡的患者)或标准护理组。

结果

在分析的137例患者中(平均年龄79±13岁,74例[54%]为女性),43例(31%)被归入CC组。获取MLUS的时间为30±22分钟。MLUS预测CC组的受试者工作特征曲线下面积为0.97(0.92 - 0.99;p<0.01),临界值严格设定在17以上,敏感性为93%(81 - 99),特异性为99%(94 - 100),阳性预测值为98%(87 - 100),阴性预测值为97%(91 - 99),阳性似然比为86,阴性似然比为0.07,诊断准确性为97%(93 - 99)。在多变量分析中,MLUS是CC组唯一的独立相关因素。

结论

早期肺部超声评分可预测老年呼吸困难患者在48小时内入住ICU和/或死亡的需求。

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