Zhou Qiang, Shao Yi-Chuan, Gan Zheng-Qi, Fang Li-Shu
Department of Endocrinology, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China,
Neuropsychiatr Dis Treat. 2019 Jan 14;15:227-231. doi: 10.2147/NDT.S193114. eCollection 2019.
Depression is commonly observed among patients with gout. Low levels of vitamin D have been associated with depression in non-gout subjects. We examined the association of vitamin D levels with depression in patients with gout.
We conducted a cross-sectional study of 186 gout patients at the Endocrinology Department of First Affiliated Hospital of Jiaxing University. Levels of serum 25-hydroxyvi-tamin D (25(OH)D) were determined using a competitive protein-binding assay. The 17-item Hamilton Depression Scale was used for screening for depressive symptoms. Diagnosis of depression in gout patients was made in accordance with criteria for depression. Multivariate analysis was performed using logistic regression models.
Thirty-two gout patients (17.2%) were diagnosed as having depression. Patients with depression showed significantly lower 25(OH)D levels as compared to patients without depression (46.4±19.0 vs 57.0±17.3 nmol/L, <0.001). Significant differences in 25(OH)D quartiles of gout patients were observed between the patients with depression and the patients without depression (=0.003). In multivariate analyses, serum 25(OH)D levels (≤40.0 nmol/L) were independently associated with depression in patients with gout (OR 3.833, 95% CI 1.406-10.453, =0.009).
Our study demonstrates an important association between serum vitamin D levels and depression in patients with gout.
痛风患者中常见抑郁症。在非痛风患者中，低水平的维生素D与抑郁症有关。我们研究了痛风患者维生素D水平与抑郁症之间的关联。
我们对嘉兴学院第一附属医院内分泌科的186例痛风患者进行了一项横断面研究。采用竞争性蛋白结合分析法测定血清25-羟基维生素D（25(OH)D）水平。使用17项汉密尔顿抑郁量表筛查抑郁症状。痛风患者的抑郁症诊断按照抑郁症标准进行。使用逻辑回归模型进行多变量分析。
32例痛风患者（17.2%）被诊断为患有抑郁症。与无抑郁症的患者相比，抑郁症患者的25(OH)D水平显著更低（46.4±19.0对57.0±17.3 nmol/L，<0.001）。抑郁症患者与无抑郁症患者之间痛风患者的25(OH)D四分位数存在显著差异（=0.003）。在多变量分析中，血清25(OH)D水平（≤40.0 nmol/L）与痛风患者的抑郁症独立相关（比值比3.833，95%置信区间1.406 - 10.453，=0.009）。
我们的研究表明痛风患者血清维生素D水平与抑郁症之间存在重要关联。
