Xu Jun, Zhu Xiang-Yun, Sun Hui, Xu Xiao-Qin, Xu Song-Ao, Suo Yuan, Cao Li-Jun, Zhou Qiang, Yu Hui-Jie, Cao Wei-Zhong
Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.
Department of Endocrinology, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.
BMC Endocr Disord. 2018 Nov 26;18(1):87. doi: 10.1186/s12902-018-0314-7.
Cognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT.
We recruited 194 patients with HT and 200 healthy volunteers. Levels of serum 25-hydroxyvitamin D (25(OH)D) were measured using a competitive protein-binding assay. Cognitive funtion was assessed using Montreal Cognitive Assessment score (MoCA). Subjects with a MoCA scores < 26 are considered as having mild cognitive impairment (MCI). Multivariate analysis was performed using logistic regression models.
Fifty-five HT patients (28.4%) were diagnosed as having MCI. Patients with MCI had significantly lower 25(OH)D levels when compared with patients without MCI (33.9 ± 6.2 vs. 44.3 ± 9.6 nmol/L, P < 0.001). Significant differences in 25(OH)D quartiles of HT patients were observed between the patients with MCI and the patients without MCI (P < 0.001). In multivariate analyses, serum 25(OH)D levels (≤ 34.0 and ≥ 47.1 nmol/L) were significantly associated with cognitive impairment in patients with HT (OR 6.279, 95% CI 2.673-14.834, P < 0.001; OR 0.061, 95% CI 0.008-0.491, P = 0.009, respectively).
Our results demonstrate an important association between serum vitamin D levels and cognitive impairment in patients with HT.
在桥本甲状腺炎（HT）患者中普遍观察到认知障碍。维生素D水平低与非HT人群的认知障碍相关。我们研究了HT患者维生素D水平与认知障碍之间的关联。
我们招募了194例HT患者和200名健康志愿者。使用竞争性蛋白结合测定法测量血清25-羟基维生素D（25(OH)D）水平。使用蒙特利尔认知评估量表（MoCA）评估认知功能。MoCA评分<26分的受试者被视为患有轻度认知障碍（MCI）。使用逻辑回归模型进行多变量分析。
55例HT患者（28.4%）被诊断为患有MCI。与无MCI的患者相比，MCI患者的25(OH)D水平显著更低（33.9±6.2 vs. 44.3±9.6 nmol/L，P<0.001）。在MCI患者和无MCI的患者之间观察到HT患者25(OH)D四分位数的显著差异（P<0.001）。在多变量分析中，血清25(OH)D水平（≤34.0和≥47.1 nmol/L）与HT患者的认知障碍显著相关（OR 6.279，95%CI 2.673-14.834，P<0.001；OR 0.061，95%CI 0.008-0.491，P=0.009）。
我们的结果表明血清维生素D水平与HT患者的认知障碍之间存在重要关联。
