Mihăilă Bianca, Dinică Rodica Mihaela, Tatu Alin Laurențiu, Buzia Olimpia Dumitriu
SC Ecofarmacia Network SRL, 550253 Sibiu, Romania.
Department of Chemistry, Faculty of Sciences and Environment, 'Dunărea de Jos' University of Galați, 800201 Galați, Romania.
Exp Ther Med. 2019 Feb;17(2):1039-1044. doi: 10.3892/etm.2018.6977. Epub 2018 Nov 16.
Although vitiligo is one of the most frequently occurring depigmentary disorder, its pathophysiology is still not fully clarified, resulting in the incapacity to find a targeted cure. Most of the treatment options available at the time have an anti-inflammatory or immunosuppressive effect, influencing the immune factor in vitiligo but without having a direct effect on melanocyte differentiation, migration or proliferation. This study shows that (PN) extract and its main alkaloid, piperine, promote melanocyte proliferation , being consistent with previous study. A PN fruit extract and pure piperine were integrated in two different ointments and tested on human subjects affected by vitiligo. A number of 9 areas were treated: 3 using the extract, 3 using pure piperine, 1 using travoprost solution, and 2 using an association of travoprost (prostaglandin F2α analogue) solution and our products. Pigmentation was achieved in all the treated areas. The extract caused faster and more remarkable results than the pure piperine. The association of the travoprost solution speed up the process and changed the pigmentation pattern, especially when associated with the PN extract. Our early studies suggest that PN extract may represent, in the future, a new treatment option for vitiligo, especially considering the mild side effects of the tested products and the reduced amount of time needed for repigmentation. However, more studies are needed to validate this experimental data.
尽管白癜风是最常见的色素脱失性疾病之一，但其病理生理学仍未完全阐明，导致无法找到针对性的治愈方法。当时可用的大多数治疗选择都具有抗炎或免疫抑制作用，影响白癜风中的免疫因子，但对黑素细胞的分化、迁移或增殖没有直接影响。本研究表明，（PN）提取物及其主要生物碱胡椒碱可促进黑素细胞增殖，这与先前的研究一致。将PN果实提取物和纯胡椒碱制成两种不同的药膏，并在白癜风患者身上进行测试。共治疗了9个部位：3个使用提取物，3个使用纯胡椒碱，1个使用曲伏前列素溶液，2个使用曲伏前列素（前列腺素F2α类似物）溶液与我们产品的组合。所有治疗部位均实现了色素沉着。提取物比纯胡椒碱产生的效果更快且更显著。曲伏前列素溶液的组合加速了这一过程并改变了色素沉着模式，尤其是与PN提取物联合使用时。我们早期的研究表明，PN提取物未来可能成为白癜风的一种新治疗选择，特别是考虑到受试产品的轻微副作用以及色素恢复所需的时间减少。然而，需要更多研究来验证这些实验数据。
