Solomon Iulia, Ilie Mihaela Adriana, Draghici Carmen, Voiculescu Vlad Mihai, Căruntu Constantin, Boda Daniel, Zurac Sabina
Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Dermatology Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Exp Ther Med. 2019 Feb;17(2):1078-1084. doi: 10.3892/etm.2018.6980. Epub 2018 Nov 16.
Atopic dermatitis (AD) is a multifactorial chronic inflammatory disease with an incompletely understood etiopathogenesis. With a significant impact on the quality of life of patients, AD has attracted the interest of many research studies aiming to investigate the complex cellular and molecular mechanisms and to identify new therapeutic pathways. Various studies have focused on psycho-immunology, emphasizing the involvement of stress, defined as a general response of the body to external or internal challenges to the AD pathology. Factors like lifestyle and leisure activities may change the behavior of immune cells in AD with a strong impact on the evolution of the disease. Moreover, the poor adherence of AD patient to standard treatment approach has led to the necessity to combine different therapies in the field of complementary and alternative medicine. Although there are still not enough data to conclude that adjuvant therapies are effective in a conventional sense, there are already promising results suggesting that alternative therapeutic strategies could be a main subject of further research.
特应性皮炎（AD）是一种多因素慢性炎症性疾病，其发病机制尚未完全明确。AD对患者的生活质量有重大影响，吸引了许多旨在研究复杂细胞和分子机制并确定新治疗途径的研究。各种研究都集中在心理免疫学上，强调压力的影响，压力被定义为身体对AD病理的外部或内部挑战的一般反应。生活方式和休闲活动等因素可能会改变AD中免疫细胞的行为，对疾病的发展产生强烈影响。此外，AD患者对标准治疗方法的依从性差，导致有必要在补充和替代医学领域结合不同疗法。尽管目前尚无足够数据得出辅助疗法在传统意义上有效的结论，但已有一些有前景的结果表明，替代治疗策略可能是进一步研究的主要课题。
