Lim Jun Jie, Lim Sing Wei, Reginald Kavita, Say Yee-How, Liu Mei Hui, Chew Fook Tim
Department of Biological Sciences Faculty of Science National University of Singapore Singapore Singapore.
Department of Biological Sciences School of Medicine and Life Sciences Sunway University Petaling Jaya Malaysia.
Skin Health Dis. 2024 Jun 26;4(4):e330. doi: 10.1002/ski2.330. eCollection 2024 Aug.
BACKGROUND & OBJECTIVE: Numerous evidence has attributed diets with a high fatty acids (FAs) intake to be associated with atopic dermatitis (AD) development. Therefore, this study investigated the association between intake frequencies of five dietary FAs and AD exacerbations among young Chinese adults from Singapore and Malaysia.
A validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was investigator-administered to 13,561 subjects to collect information on socioeconomic, anthropometric, dietary and lifestyles habits, and personal/family medical histories. Six novel dietary indices were derived to analyse the associations between total FAs, trans fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids, linoleic acids, and alpha-linolenic acids in diets and AD exacerbation. Synergy factor (SF) analysis was used to identify interactions between the dietary FAs to influence disease susceptibility.
In our multivariable model adjusted for age, gender, BMI, parental eczema, and lifestyle factors, a diet high in total estimated FAs was strongly associated with AD (Adjusted Odds Ratio (AOR): 1.227; 95% Confidence Interval (CI): 1.054-1.429; adjusted -value <0.01). Particularly, high estimated total TFAs and SFAs were significantly associated with AD exacerbations including chronic and current moderate-to-severe AD. The association between TFAs and AD remained strong even controlled for the total FAs in diets and false discovery rate corrected (AOR: 1.516; 95% CI: 1.094-2.097; adjusted -value <0.05). Similarly, having a high SFAs in diets was associated with AD (AOR: 1.581; 95% CI: 1.106-2.256; adjusted -value <0.05) independently on the total FAs in diets. FAs in diets do not interact to influence AD.
Overall, these results highlighted an association between high dietary TFAs and SFAs and AD exacerbations in an Asian population.
大量证据表明，高脂肪酸（FAs）摄入的饮食与特应性皮炎（AD）的发生有关。因此，本研究调查了新加坡和马来西亚年轻中国成年人中五种膳食脂肪酸的摄入频率与AD病情加重之间的关联。
研究人员向13561名受试者发放经过验证的儿童哮喘和过敏国际研究（ISAAC）问卷，以收集社会经济、人体测量、饮食和生活方式习惯以及个人/家族病史等信息。推导了六个新的饮食指数，以分析饮食中总脂肪酸、反式脂肪酸（TFAs）、饱和脂肪酸（SFAs）、单不饱和脂肪酸、亚油酸和α-亚麻酸与AD病情加重之间的关联。采用协同因子（SF）分析来确定膳食脂肪酸之间影响疾病易感性的相互作用。
在我们针对年龄、性别、体重指数、父母湿疹和生活方式因素进行调整的多变量模型中，估计总脂肪酸含量高的饮食与AD密切相关（调整后的优势比（AOR）：1.227；95%置信区间（CI）：1.054 - 1.429；调整后p值<0.01）。特别是，估计的总TFAs和SFAs含量高与AD病情加重显著相关，包括慢性和当前中度至重度AD。即使在控制饮食中总脂肪酸并校正错误发现率后，TFAs与AD之间的关联仍然很强（AOR：1.516；95%CI：1.094 - 2.097；调整后p值<0.05）。同样，饮食中高含量的SFAs与AD相关（AOR：1.581；95%CI：1.106 - 2.256；调整后p值<0.05），独立于饮食中的总脂肪酸。饮食中的脂肪酸之间不存在相互作用来影响AD。
总体而言，这些结果突出了亚洲人群中高膳食TFAs和SFAs与AD病情加重之间的关联。
