Xu Xuegu, Cai Yonghao
Department of Pharmacy, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325003, P.R. China.
Exp Ther Med. 2019 Feb;17(2):1224-1227. doi: 10.3892/etm.2018.7079. Epub 2018 Dec 10.
Therapeutic effects and safety of houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis (VK) were evaluated. A total of 926 patients with VK were collected in the Eye Hospital of Wenzhou Medical University from July 2011 to January 2017. Patients were divided into group A, B and C according to the use of different eye drops. Group A included 276 patients who were treated with houttuynia eye drops; group B included 305 patients who were treated with olopatadine hydrochloride eye drops; group C included 345 patients who were treated with houttuynia eye drops and olopatadine hydrochloride eye drops. Treatment was performed for 14 days. Eye symptoms before and after treatment, and at 1 h, 7 days and 14 days after drug administration were compared among groups to evaluate the therapeutic effect. At 1 h after drug administration, highest excellent rate was observed in group C, followed by group A, and good outcome rate was significantly higher in group C than in the other two groups (P<0.05), and effective rate was also significantly higher in group C than in the other two groups (P<0.05). At 7 days after treatment, excellent rate was significantly higher in group C than in the other two groups (P<0.05), and effective rate was higher in group C than in group B (P<0.05). At 14 days after treatment, excellent rate was significantly higher in group C than in the other two groups (P<0.05), while lowest good outcome rate and ineffective rate were found in group C, and no significant differences were found between group A and B (P>0.05). Houttuynia ophthalmic solution and olopatadine hydrochloride eye drops can both achieve good effect in the treatment of VK, and combined use of them can increase the efficacy and shorten treatment period. So, the combined treatment should be popularized.
评价了鱼腥草滴眼液联合盐酸奥洛他定滴眼液治疗春季角结膜炎（VK）的疗效及安全性。2011年7月至2017年1月，温州医科大学附属眼视光医院共收集了926例VK患者。根据使用不同滴眼液将患者分为A组、B组和C组。A组276例，接受鱼腥草滴眼液治疗；B组305例，接受盐酸奥洛他定滴眼液治疗；C组345例，接受鱼腥草滴眼液和盐酸奥洛他定滴眼液联合治疗。治疗14天。比较各组治疗前后及给药后1小时、7天和14天的眼部症状，以评估治疗效果。给药后1小时，C组的优秀率最高，其次是A组，C组的良好结局率显著高于其他两组（P<0.05），有效率也显著高于其他两组（P<0.05）。治疗后7天，C组的优秀率显著高于其他两组（P<0.05），C组的有效率高于B组（P<0.05）。治疗后14天，C组的优秀率显著高于其他两组（P<0.05），而C组的良好结局率和无效率最低，A组和B组之间无显著差异（P>0.05）。鱼腥草滴眼液和盐酸奥洛他定滴眼液在治疗VK方面均能取得良好效果，两者联合使用可提高疗效并缩短治疗周期。因此，联合治疗应予以推广。
