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球囊椎体后凸成形术后的肺水泥栓塞:一种手术并发症在肺癌治疗新时代的影响

Pulmonary cement embolism following balloon kyphoplasty: The impact of a procedural complication in a new era for lung cancer management.

作者信息

Rodrigues Daniela Marta, Cunha Machado Daniela Patrícia, Campainha Fernandes Sérgio André, Paixão Barroso Ana Maria

机构信息

Department of Pulmonology, Hospital Pedro Hispano, São Mamede de Infesta, 4465-120 Matosinhos, Portugal.

Multidisciplinary Unit of Thoracic Tumors, Department of Pulmonology, Centro Hospitalar Vila Nova de Gaia/Espinho, 4434-502 Vila Nova de Gaia, Portugal.

出版信息

Mol Clin Oncol. 2019 Feb;10(2):299-303. doi: 10.3892/mco.2018.1782. Epub 2018 Nov 30.

Abstract

Pulmonary cement embolism (PCE) is a recognized complication of balloon kyphoplasty, a vertebral augmentation technique that stabilizes vertebral compression fractures, alleviating associated pain. Balloon kyphoplasty is particularly relevant when patients with advanced stages of cancer present with longer survival times, and therefore benefit from such augmentation techniques to improve pain and prevent additional complications. The embolization of cement to pulmonary vasculature may be unnoticed given the frequent absence of symptoms and routine imaging tests following the procedure. The present study reports the case of a 58-year-old female with stage IV lung cancer with a painful compression L3 fracture who underwent balloon kyphoplasty with no initially reported complications. The patient maintained the usual respiratory symptoms; therefore, the diagnosis was only made in a routine CT scan 3 months after the surgery. A literature review of PCE is performed, integrating the current evidence regarding diagnosis, therapeutics, prognosis and prevention. Certain poorly clarified aspects are identified as potential investigation starting points.

摘要

肺水泥栓塞(PCE)是球囊后凸成形术公认的并发症,球囊后凸成形术是一种稳定椎体压缩性骨折、缓解相关疼痛的椎体强化技术。当癌症晚期患者生存期延长时,球囊后凸成形术尤为适用,因此这类患者可受益于此类强化技术来缓解疼痛并预防其他并发症。由于术后常无症状且缺乏常规影像学检查,水泥栓塞至肺血管可能未被察觉。本研究报告了一例58岁IV期肺癌女性患者,该患者L3椎体发生疼痛性压缩性骨折,接受了球囊后凸成形术,最初未报告有并发症。患者维持着常见的呼吸道症状;因此,诊断仅在术后3个月的常规CT扫描中才得以做出。本文对PCE进行了文献综述,整合了有关诊断、治疗、预后和预防的现有证据。确定了某些尚未明确的方面作为潜在的研究起点。

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