Atarbashi Moghadam Saede, Ghorbanpour Maedeh
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dept. of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
J Dent (Shiraz). 2018 Dec;19(4):253-258.
Central giant cell granuloma of the jaws is comprised of two types namely aggressive and nonaggressive. Controversy exists regarding the histogenesis of this lesion. Up to now, there are no reliable histologic or molecular methods to differentiate aggressive from nonaggressive central giant cell granuloma of the jaw. Moreover, because of different treatment of two groups, correct diagnosis is needed.
The purpose of this study was to evaluate and compare the expression of cyclin D1 between aggressive and nonaggressive central giant cell granulomas of the jaws.
This retrospective study was performed on 16 paraffin blocks of aggressive central giant cell granuloma, and 16 nonaggressive central giant cell granulomas from Shahid Beheshti Oral Pathology Department and evaluated the expression of cyclin D1 on giant cells and mononuclear cells of the lesions. T-test was used for quantitative evaluation and comparison of cyclin D1 expression between two groups.
Overexpression of cyclin D1 in giant cells and mononuclear cells of the lesions of both groups was apparent, but no significant statistical difference was seen. Cyclin D1 positivity was seen predominantly in the nuclei of giant cells. When a giant cell was positive, all the nuclei showed immunoreactivity. In each group mean percentage of the positive giant cells were higher than positive mononuclear cells and significant statistical difference (= 0.000) was seen between them.
Probably overexpression of cyclin D1 implicates in the pathogenesis of the central giant cell granulomas but it seems that this protein could not be used as a marker for identifying the clinical behavior of these lesions.
颌骨中央巨细胞肉芽肿由侵袭性和非侵袭性两种类型组成。关于该病变的组织发生存在争议。到目前为止，尚无可靠的组织学或分子方法来区分颌骨侵袭性与非侵袭性中央巨细胞肉芽肿。此外，由于两组的治疗方法不同，需要进行正确的诊断。
本研究的目的是评估和比较颌骨侵袭性与非侵袭性中央巨细胞肉芽肿中细胞周期蛋白D1的表达。
本回顾性研究对来自沙希德·贝赫什提口腔病理科的16个侵袭性中央巨细胞肉芽肿石蜡块和16个非侵袭性中央巨细胞肉芽肿进行研究，评估病变中巨细胞和单核细胞中细胞周期蛋白D1的表达。采用t检验对两组细胞周期蛋白D1表达进行定量评估和比较。
两组病变的巨细胞和单核细胞中细胞周期蛋白D1均有明显过表达，但未见显著统计学差异。细胞周期蛋白D1阳性主要见于巨细胞核。当一个巨细胞呈阳性时，所有细胞核均显示免疫反应性。每组中阳性巨细胞的平均百分比高于阳性单核细胞，两者之间存在显著统计学差异（P = 0.000）。
细胞周期蛋白D1的过表达可能与中央巨细胞肉芽肿的发病机制有关，但该蛋白似乎不能用作识别这些病变临床行为的标志物。
