Kruse-Lösler Birgit, Diallo Raihanatou, Gaertner Christoph, Mischke Karl-Ludwig, Joos Ulrich, Kleinheinz Johannes
Department of Craniomaxillofacial Surgery, University of Münster, Münster, Germany.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):346-54. doi: 10.1016/j.tripleo.2005.02.060.
The clinical behavior of central giant cell granuloma (CGCG) of the jaws is variable and difficult to predict. Clinical data and follow-up information of 26 patients with CGCG were analyzed. Histologic features were correlated with the clinical course of the disease. In 16 patients the CGCGs were asymptomatic; 10 lesions presented with aggressive growth, pain, massive swelling, root resorption, cortical perforation, and/or recurrence. These patients were younger and the lesions were larger than in the nonaggressive group. The histomorphometric analysis proved a significant increase in large giant cells, fractional surface area, and mitotic activity in aggressive CGCG lesions. Immunohistologic investigation (Ki-67 and p53 stain) revealed no significant differences. After surgical treatment, 3 patients with aggressive lesions developed a recurrence. The data show that clinical and histomorphometric features may be reliable indicators for the differentiation between aggressive and nonaggressive CGCG. This should be accounted for to improve the individual planning of the treatment and follow-up.
颌骨中心性巨细胞肉芽肿（CGCG）的临床行为具有多样性且难以预测。分析了26例CGCG患者的临床资料及随访信息。组织学特征与疾病的临床进程相关。16例患者的CGCG无症状；10个病变表现为侵袭性生长、疼痛、大量肿胀、牙根吸收、皮质穿孔和/或复发。这些患者较年轻，病变比非侵袭性组更大。组织形态计量学分析证明，侵袭性CGCG病变中的大巨细胞、表面积分数和有丝分裂活性显著增加。免疫组织学研究（Ki-67和p53染色）未显示出显著差异。手术治疗后，3例侵袭性病变患者出现复发。数据表明，临床和组织形态计量学特征可能是区分侵袭性和非侵袭性CGCG的可靠指标。在制定个体化治疗和随访计划时应考虑到这一点。
