[Effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer and on immune regulation].

PURPOSE

To study the effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer (ROU) and on immunological regulation.

METHODS

This randomized controlled clinical study prospectively enrolled 204 patients with ROU who were randomly divided into 2 groups. Patients in group A received Garlicin Capsules 1/time, 3 times/d, combined with Kangfuxin liquid 10 mL to gargle 3 times/d; patients in group B only received Kangfuxin liquid 10 mL gargle 5 min, 3/d. The treatment lasted for 2 weeks. The curative effect was compared before and after treatment, including ulcer surface pain (VAS score), time of ulcer healing, and the changes of T cell subsets (CD3, CD4, CD8 and CD4/CD8) before and after treatment were compared by SPSS 22 software package.

RESULTS

Ulcer healing time (3.5±0.6) d, duration of pain (3.1±0.3)d in group A were shorter than in group B (P<0.05); treatment efficiency was 96.08% in group A, 88.24% in group B( χ=6.264, P<0.05). The pain scores of both groups were significantly reduced after treatment, and the difference was significant between group A and group B [(1.1±0.4) vs (3.2± 0.6)] (P<0.05). The levels of CD3, CD4, CD4/CD8 in group A were significantly higher than those in group A after treatment (P<0.05), the levels of CD8+ was significant lower than in group B (P<0.05).

CONSLUSIONS

Kangfuxin liquid combined with Garlicin Capsules can improve the therapeutic effect of ROU and repair of local damaged mucosa in children, increasing the immune function of children.