State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, China.
School of Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Anal Bioanal Chem. 2019 Jul;411(18):3993-4006. doi: 10.1007/s00216-019-01577-9. Epub 2019 Jan 25.
The failure of complete tumor resection during cancer surgery is a leading cause of lethal recurrence and metastasis. However, achieving accurate delineation of tumor margins intraoperatively remains extremely difficult because the infiltrated nature of a tumor usually gives an obscure margin and spreading microtumors. Recent studies show that surface-enhanced Raman scattering (SERS) has the potential to depict precisely the actual tumor extent with high sensitivity, specificity, and spatial resolution; thus providing a promising platform to improve the therapeutic efficiency. In this review, we discuss the recent progress in the use of SERS spectroscopy for intraoperative image-guided resection. We highlight key successes in the development of SERS tags and give insights into the design mechanism of rational SERS tags. We also discuss how to improve the performance of intraoperative navigation based on SERS and explore the challenges and future opportunities for the development of a more effective SERS-based platform. Graphical abstract ᅟ.
肿瘤手术中未能完全切除肿瘤是导致致命性复发和转移的主要原因。然而，由于肿瘤的浸润性质通常会导致边界模糊和扩散的微肿瘤，因此术中准确描绘肿瘤边界仍然极其困难。最近的研究表明，表面增强拉曼散射（SERS）具有以高灵敏度、特异性和空间分辨率精确描绘实际肿瘤范围的潜力；从而为提高治疗效率提供了一个有前途的平台。在这篇综述中，我们讨论了 SERS 光谱在术中图像引导切除中的最新进展。我们强调了 SERS 标签发展的关键成功，并深入了解了合理 SERS 标签的设计机制。我们还讨论了如何基于 SERS 提高术中导航的性能，并探讨了开发更有效的基于 SERS 平台的挑战和未来机遇。
