Xi Xi, Liang Chongyang
Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
School of pharmaceutical science, Institute of Frontier Medical Science, Jilin University, Changchun, China.
Front Chem. 2021 Jul 20;9:665841. doi: 10.3389/fchem.2021.665841. eCollection 2021.
Raman spectroscopy has emerged as a promising tool in biomedical analysis and clinical diagnosis. The development of surface-enhanced Raman scattering spectroscopy (SERS) improved the detection limit with ultrahigh sensitivity and simplicity. More and more Raman spectroscopy clinical trials (R-PCT) have been conducted recently. However, there is a lack of an up-to-date review summarizing the current status of Raman clinical trials performed until now. Hence, the clinical trials for Raman were retrieved from the International Clinical Trials Registration Platform. We summarized the clinical characteristics of 55 registered Raman spectroscopy clinical trials (R-RSCTs) and 44 published Raman spectroscopy clinical trials (P-RSCTs). This review could assist researchers and clinicians to understand the current status of Raman spectroscopy clinical research and perhaps could benefit the reasonable and accurate design of future SERS studies.
拉曼光谱已成为生物医学分析和临床诊断中一种很有前景的工具。表面增强拉曼散射光谱（SERS）的发展以超高灵敏度和简便性提高了检测限。最近进行了越来越多的拉曼光谱临床试验（R-PCT）。然而，目前缺乏一篇最新综述来总结迄今为止所进行的拉曼临床试验的现状。因此，从国际临床试验注册平台检索了拉曼临床试验。我们总结了55项注册拉曼光谱临床试验（R-RSCT）和44项已发表拉曼光谱临床试验（P-RSCT）的临床特征。这篇综述可以帮助研究人员和临床医生了解拉曼光谱临床研究的现状，也许有助于未来SERS研究的合理准确设计。
