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[具有抗真菌活性的新型 N-吡唑基水杨酰胺]

[Novel N-pyrazolylsalicylamides with antifungal activity].

作者信息

Daidone G, Plescia S, Raffa D, Bajardi M L, Milici M

出版信息

Farmaco Sci. 1985 Sep;40(9):683-94.

PMID:3908143
Abstract

A number of new N-pyrazolylsalicylamides were prepared by fusion of phenyl salicylate and aminopyrazoles. The condensation reaction is influenced by the substitution at the C-4 position of the aminopyrazole. All the substances obtained were tested for antifungal activity against Cryptococcus neoformans and Candida albicans. It was found that their fungitoxicity is dependent on the structural feature.

摘要

通过水杨酸苯酯与氨基吡唑的熔融反应制备了一系列新型N-吡唑基水杨酰胺。缩合反应受氨基吡唑C-4位取代基的影响。对所得到的所有物质进行了抗新型隐球菌和白色念珠菌的抗真菌活性测试。发现它们的杀真菌毒性取决于结构特征。

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