Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA), UBA-CONICET, Cdad. Autónoma de Buenos Aires, Buenos Aires, Argentina.
Pest Manag Sci. 2019 Jul;75(7):1887-1893. doi: 10.1002/ps.5359. Epub 2019 Mar 13.
The house mouse (Mus musculus) is a cosmopolitan rodent that has become adapted to living in close association with humans and is considered a serious pest because it poses a risk to human health, and causes economic losses due to food and crop consumption and damage to buildings. Its control in livestock farms is achieved mainly through the application of anticoagulant rodenticides, but the effect of these compounds is limited due to the presence of resistant individuals and aversive behaviours. A potential alternative method is the use of chemical signals to reduce rodent reproductive success. In this study, we assessed the effects of odours from an unfamiliar male, 17β-oestradiol, overcrowding, cat urine and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) on the reproductive success of laboratory Mus musculus females.
According to the generalized linear mixed models, cat urine odour increased the proportion of abortions per female, unfamiliar male odour decreased the mean number of offspring born per female, and TMT had an overall negative effect on mean offspring production at birth and at weaning. The other odours had no significant effects on reproductive success.
TMT seems to be the best candidate for population control because it caused a decrease in the mean number of offspring born and the mean number of live offspring at weaning. TMT also has the advantage of being available in commercial forms. To be useful for rodent management in field conditions, these results should be confirmed using wild house mice females. © 2019 Society of Chemical Industry.
家鼠（Mus musculus）是一种世界性的啮齿动物，已适应与人类密切相关的生活，被认为是一种严重的害虫，因为它对人类健康构成威胁，并造成粮食和作物消耗以及建筑物损坏的经济损失。在养殖场中，主要通过应用抗凝血灭鼠剂来控制其数量，但由于存在抗性个体和厌恶行为，这些化合物的效果有限。一种潜在的替代方法是使用化学信号来降低啮齿动物的繁殖成功率。在这项研究中，我们评估了来自陌生雄性、17β-雌二醇、过度拥挤、猫尿和 2,5-二氢-2,4,5-三甲基噻唑啉（TMT）的气味对实验室 Mus musculus 雌性繁殖成功率的影响。
根据广义线性混合模型，猫尿气味增加了每只雌性的流产比例，陌生雄性气味减少了每只雌性出生的后代平均数量，而 TMT 对出生时和断奶时的后代平均产量产生了总体负面影响。其他气味对繁殖成功率没有显著影响。
TMT 似乎是控制种群的最佳候选物，因为它导致出生的后代平均数量和断奶时的活后代平均数量减少。TMT 还具有可在商业形式中获得的优势。为了在野外条件下对鼠类管理有用，这些结果应使用野生家鼠雌性来确认。© 2019 英国化学学会。
