血吸虫性肝纤维化患者的胃液分泌及基础胃泌素浓度
Gastric secretion and basal gastrin concentration in bilharzial hepatic fibrosis.
作者信息
Boulos P B, Okosdonossian E T, Elmunshid H A, Elmasri S H, Hassan M A, Hobsley M
出版信息
Gut. 1978 Sep;19(9):802-7. doi: 10.1136/gut.19.9.802.
Gastric secretion and fasting plasma gastrin levels were investigated in 26 patients with bilharzial hepatic fibrosis and 26 controls. The groups did not differ in their basal secretion. When stimulated by intravenous infusion of histamine the maximal acid output in patients with bilharzial hepatic fibrosis was significantly less than in the control group. This was unlikely to be a result of neutralisation by reflux of alkaline duodenal contents as the volumes of reflux were not different from control subjects, but was compatible with a true reduction in gastric secretion as assessed by two-component hypothesis. Neither the lowered gastric acidity nor the liver damage in patients with bilharzial hepatic fibrosis correlated with circulating gastrin. The fasting levels of plasma gastrin in these patients were not different from controls. As in other liver diseases the cause of diminished gastric secretion remains unclear.
对26例血吸虫性肝纤维化患者和26例对照者的胃分泌及空腹血浆胃泌素水平进行了研究。两组的基础分泌无差异。静脉输注组胺刺激后，血吸虫性肝纤维化患者的最大酸排量明显低于对照组。这不太可能是十二指肠碱性内容物反流中和的结果，因为反流体积与对照组无异，但与根据双组分假说评估的胃分泌真正减少相符。血吸虫性肝纤维化患者胃酸降低和肝损伤均与循环胃泌素无关。这些患者的空腹血浆胃泌素水平与对照组无差异。与其他肝脏疾病一样，胃分泌减少的原因仍不清楚。
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