类风湿关节炎中的胃酸过少和高胃泌素血症。
Hypochlorhydria and hypergastrinaemia in rheumatoid arthritis.
作者信息
de Witte T J, Geerdink P J, Lamers C B, Boerbooms A M, van der Korst J K
出版信息
Ann Rheum Dis. 1979 Feb;38(1):14-7. doi: 10.1136/ard.38.1.14.
In order to evaluate the incidence and aetiology of hypergastrinaemia 53 patients with seropositive rheumatoid arthritis were examined for gastric acid secretion, fasting serum gastrin concentration, circulating parietal cell antibodies, and some parameters of the activity of inflammation of rheumatoid arthritis. The basal and maximum acid output was found to be subnormal in this group (P less than 0.01), and in 11 of these patients (23%) the fasting serum gastrin levels were raised (P less than 0.05). This hypergastrinaemia correlated strongly with maximum acid output. Only in cases of achlorhydria or hypochlorhydria (maximum acid output less than 2 mmol/l) was the serum gastrin level markedly raised. Two out of 5 patients with achlorhydria were found to have circulating parietal cell antibodies, and 1 had decreased absorption of vitamin B12. No relationship was found between serum gastrin and duration or activity of rheumatoid arthritis; nor was there a relationship between basal serum gastrin and the various antirheumatic drugs administered.
为评估高胃泌素血症的发生率及病因，对53例血清类风湿关节炎阳性患者进行了胃酸分泌、空腹血清胃泌素浓度、循环壁细胞抗体以及类风湿关节炎炎症活动的一些参数检查。该组患者基础胃酸排出量和最大胃酸排出量均低于正常（P<0.01），其中11例患者（23%）空腹血清胃泌素水平升高（P<0.05）。这种高胃泌素血症与最大胃酸排出量密切相关。仅在无胃酸分泌或胃酸分泌过少（最大胃酸排出量<2 mmol/L）的情况下，血清胃泌素水平才会显著升高。5例无胃酸分泌患者中有2例发现循环壁细胞抗体，1例维生素B12吸收减少。未发现血清胃泌素与类风湿关节炎病程或活动度之间存在关联；基础血清胃泌素与所使用的各种抗风湿药物之间也无关联。
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