Filipponi F, Andrée M, Houssin D
Clinique Chirurgicale, Hôpital Cochin, Paris.
Ital J Surg Sci. 1988;18(4):317-22.
A technique is described for orthotopic liver transplantation in the rat using polyethylene cuffs to re-establish subhepatic cava and portal vascular anastomoses. This procedure reduces the time of portal clamping, an important factor of survival. This technique was found to be reliable with a 72.9% long-term survival (more than 60 days) in an experimental group of 59 iso- and allografts. The method was employed in 212 animals during studies on iso-, allo- and xenografts to evaluate the tolerance and rejection mechanisms in rats of pure strain.
描述了一种在大鼠中进行原位肝移植的技术，该技术使用聚乙烯套管重建肝下腔静脉和门静脉血管吻合。此手术减少了门静脉阻断时间，这是生存的一个重要因素。在一个包含59个同基因和异基因移植的实验组中，发现该技术可靠，长期存活率（超过60天）为72.9%。在对同基因、异基因和异种移植的研究中，该方法应用于212只动物，以评估纯系大鼠的耐受性和排斥机制。
