Aberdeen Centre for Women's Health Research, Institute of Applied Health Sciences; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom.
Medical Statistics Team, Institute of Applied Health Sciences; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom.
Am J Obstet Gynecol. 2019 Apr;220(4):393.e1-393.e7. doi: 10.1016/j.ajog.2019.01.215. Epub 2019 Jan 23.
Previous evidence suggests that placental dysfunction, which includes preeclampsia, is inherited from mother to daughter, but heritability of stillbirth has never been investigated.
The purpose of this study was to investigate whether there is an inherited predisposition to stillbirth that is transmitted from mother to daughter.
We carried out a nested case-control study within the intergenerational cohort held in the Aberdeen Maternity and Neonatal Databank. All mothers who had at least 1 daughter in Aberdeen, United Kingdom, between 1949 and 2000 were included. Mother-daughter pairs were linked with the use of the Scottish Community Health Index number. The main exposure was the mother's history of stillbirth. The primary outcome was stillbirth in any of the daughter's pregnancies. A population average model that used generalized estimating equations with robust standard errors was used to estimate odds of a mother's history of stillbirth in daughters with a stillbirth compared with daughters with only livebirths. This method accounted for clustering of daughters within mothers, and multi-adjusted analyses were performed to include confounders at the daughter's pregnancy level.
Among the daughters, 384 had a history of ≥1 stillbirths (cases); 26,404 only ever had livebirths (control subjects). We found no statistically significant association between mothers' history of stillbirth (adjusted odds ratio, 0.63; 95% confidence interval, 0.24-1.63) or miscarriage (adjusted odds ratio, 1.01; 95% confidence interval, 0.71-1.42) and stillbirth in daughters.
This is the first study to investigate an inherited predisposition to stillbirth. There was no evidence of an inherited predisposition to stillbirth transmitted from mother to daughter.
先前的证据表明，胎盘功能障碍（包括子痫前期）可从母亲遗传给女儿，但尚未研究过死产的遗传性。
本研究旨在调查从母亲到女儿是否存在死产的遗传易感性。
我们在阿伯丁母婴数据库中的世代间队列中进行了嵌套病例对照研究。所有在 1949 年至 2000 年间在英国阿伯丁至少有 1 个女儿的母亲都被纳入研究。使用苏格兰社区健康索引号码将母亲-女儿对进行了关联。主要暴露因素是母亲的死产史。主要结局是女儿任何一次妊娠中的死产。使用广义估计方程和稳健标准误差的群体平均模型来估计有死产史的母亲在死产女儿中的死产史与仅活产女儿中的死产史的比值比。这种方法考虑了女儿在母亲中的聚类，并且进行了多调整分析，以包括女儿妊娠水平的混杂因素。
在女儿中，有 384 人有≥1 次死产史（病例）；26404 人仅活产（对照）。我们未发现母亲死产史（调整比值比，0.63；95%置信区间，0.24-1.63）或流产史（调整比值比，1.01；95%置信区间，0.71-1.42）与女儿的死产之间存在统计学上的显著关联。
这是第一项研究遗传易感性与死产之间关系的研究。没有证据表明从母亲到女儿存在死产的遗传易感性。
