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代际青少年怀孕:基于人群的队列研究。

Intergenerational teen pregnancy: a population-based cohort study.

机构信息

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.

出版信息

BJOG. 2018 Dec;125(13):1766-1774. doi: 10.1111/1471-0528.15297. Epub 2018 Jun 25.

Abstract

OBJECTIVE

To estimate the intergenerational association in teenage pregnancy, and whether there is a coupling tendency between a mother and daughter in how their teen pregnancies end, such as a termination of pregnancy (TOP) versus a live birth.

DESIGN

Population-based cohort study.

SETTING

Ontario, Canada.

POPULATION

A total of 15 097 mothers and their 16 177 daughters.

METHODS

Generalised estimating equations generated adjusted odds ratios (aOR) of a daughter experiencing a teen pregnancy in relation to the number of teen pregnancies her mother had. Multinomial logistic regression estimated the odds that a teen pregnancy ended with TOP among both mother and daughter. All models were adjusted for maternal age and world region of origin, the daughter's socio-demographic characteristics and comorbidities, mother-daughter cohabitation, and neighbourhood-level teen pregnancy rate.

MAIN OUTCOME MEASURES

Teen pregnancy in the daughter, between ages 15 and 19 years, and also the nature of the daughter's teen pregnancy, categorised as (1) no teen pregnancy, (2) at least one teen pregnancy, all exclusively ending with a live birth, and (3) at least one teen pregnancy, with at least one teen pregnancy ending with a TOP.

RESULTS

The proportion of daughters having a teen pregnancy among those whose mother had zero, one, two, or at least three teen pregnancies was 16.3, 24.9, 33.5 and 36.3%, respectively. The aOR of a daughter having a teen pregnancy was 1.42 (95% CI 1.25-1.61) if her mother had one, 1.97 (95% CI 1.71-2.26) if she had two, and 2.17 (95% CI 1.84-2.56) if her mother had three or more teen pregnancies, relative to none. If a mother had at least one teen pregnancy ending with TOP, then her daughter had an aOR of 2.12 (95% CI 1.76-2.56) for having a teen pregnancy also ending with TOP; whereas, if a mother had at least one teen pregnancy, all ending with a live birth, then her daughter had an aOR of 1.73 (95% CI 1.46-2.05) for that same outcome.

CONCLUSION

There is a strong intergenerational occurrence of teenage pregnancy between a mother and daughter, including a coupling tendency in how the pregnancy ends.

TWEETABLE ABSTRACT

Strong intergenerational association for teenage pregnancy between mother and daughter.

摘要

目的

估计少女怀孕的代际关联,以及母亲和女儿的青少年怀孕结局之间是否存在耦合趋势,例如终止妊娠(TOP)与活产。

设计

基于人群的队列研究。

地点

加拿大安大略省。

人群

共有 15097 名母亲及其 16177 名女儿。

方法

广义估计方程生成了女儿经历青少年怀孕的调整优势比(aOR),与母亲经历的青少年怀孕次数有关。多项逻辑回归估计了母亲和女儿中青少年怀孕以 TOP 结束的几率。所有模型均根据母亲年龄和原籍世界区域、女儿的社会人口特征和合并症、母女同居情况以及邻里青少年怀孕率进行了调整。

主要结果测量

女儿在 15 至 19 岁之间的青少年怀孕,以及女儿的青少年怀孕性质,分为(1)无青少年怀孕,(2)至少一次青少年怀孕,均仅以活产结束,和(3)至少一次青少年怀孕,至少一次青少年怀孕以 TOP 结束。

结果

在母亲有零、一、二或至少三次青少年怀孕的情况下,其女儿中有青少年怀孕的比例分别为 16.3%、24.9%、33.5%和 36.3%。如果母亲有一次青少年怀孕,女儿发生青少年怀孕的 aOR 为 1.42(95%CI 1.25-1.61);如果她有两次,aOR 为 1.97(95%CI 1.71-2.26);如果她有三次或更多次青少年怀孕,aOR 为 2.17(95%CI 1.84-2.56),与无青少年怀孕相比。如果母亲至少有一次青少年怀孕以 TOP 结束,那么她的女儿发生青少年怀孕也以 TOP 结束的 aOR 为 2.12(95%CI 1.76-2.56);而如果母亲至少有一次青少年怀孕,均以活产结束,那么她的女儿发生相同结局的 aOR 为 1.73(95%CI 1.46-2.05)。

结论

母亲和女儿之间存在强烈的青少年怀孕代际发生,包括怀孕结局的耦合趋势。

推文摘要

母亲和女儿之间青少年怀孕的代际关联很强。

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