College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province, 163319, PR China.
Daqing Animal Husbandry and Veterinary Bureau, No. 26 Yu Cai Road, Saertu District, Daqing, 163311, China.
Microb Pathog. 2019 Apr;129:43-49. doi: 10.1016/j.micpath.2019.01.017. Epub 2019 Jan 23.
Porcine epidemic diarrhea results from infection with porcine epidemic diarrhea virus (PEDV). It is an acute and highly contagious enteric disease in swine characterized by watery diarrhea and vomiting. Here, we performed a systematic review and meta-analysis in order to assess the prevalence of PEDV infection in pig populations from mainland China.
We conducted a literature search on the prevalence of PEDV infection in pigs between Jan 1, 1988 and Aug 20, 2018 in English and Chinese databases, including PubMed, Google scholar, Cochrane library, Clinical Trials, VIP, CNKI and WanFang database. Selections were made based on the title and the abstract of paper, and duplicated literature was excluded along with other host studies, and data incomplete literature according to the exclusion criteria we formulated. Finally, we extracted the number of swine with PEDV infection from the obtained studies and provided information that permitted us to estimate the prevalence of PEDV infection in pigs in mainland China.
A total of 45 studies (including data from 15,990 pigs) met our evaluation criteria. In China, the overall estimated prevalence of PEDV infection in pigs was 44% (7113/15,990), while the estimated prevalence of PEDV infection in pigs from northern China was 37% (793/2136), lower than those in other regions of China. The prevalence of PEDV infection was associated with sampling season, category of pigs and clinical signs (diarrhea) in pigs. However, the prevalence of PEDV among pigs in China was not significantly associated with the effect of detected target genes, nor was it associated with date of study publication.
Our findings suggest that PEDV infection is common among pigs in China. It is therefore necessary to carry out further research and monitor the prevalence of PEDV infection. Furthermore, powerful and effective regulatory measures should be taken in order to prevent the transmission and spread of PEDV among pig populations.
猪流行性腹泻是由猪流行性腹泻病毒（PEDV）引起的。它是一种在猪中发生的急性和高度传染性的肠病，其特征是水样腹泻和呕吐。在这里，我们进行了一项系统评价和荟萃分析，以评估中国内地猪群中 PEDV 感染的流行率。
我们在 1988 年 1 月 1 日至 2018 年 8 月 20 日期间，在英文和中文数据库中（包括 PubMed、Google Scholar、Cochrane 图书馆、临床试验、VIP、CNKI 和万方数据库）进行了关于猪PEDV 感染流行率的文献检索。根据论文的标题和摘要进行了选择，并排除了重复文献以及根据我们制定的排除标准其他宿主研究和数据不完整的文献。最后，我们从获得的研究中提取了感染 PEDV 的猪的数量，并提供了信息，使我们能够估计中国内地猪群中 PEDV 感染的流行率。
共有 45 项研究（包括来自 15990 头猪的数据）符合我们的评估标准。在中国，猪PEDV 感染的总体估计流行率为 44%（7113/15990），而中国北方猪的 PEDV 感染估计流行率为 37%（793/2136），低于中国其他地区。PEDV 感染的流行率与采样季节、猪的类别和猪的临床症状（腹泻）有关。然而，PEDV 在猪中的流行率与检测靶基因的效果无关，也与研究发表日期无关。
我们的研究结果表明，PEDV 感染在中国猪群中很常见。因此，有必要进行进一步的研究和监测 PEDV 感染的流行率。此外，应采取有力和有效的监管措施，防止 PEDV 在猪群中的传播和扩散。
