Bloesch D, Schutz Y, Breitenstein E, Jéquier E, Felber J P
Department of Internal Medicine, University Hospital, Lausanne, Switzerland.
J Am Coll Nutr. 1988 Dec;7(6):471-83. doi: 10.1080/07315724.1988.10720263.
To investigate the effect of age and change in body composition on the increase in energy expenditure consecutive to the ingestion of a 75-g glucose load, respiratory exchange measurements were performed on 24 subjects, 12 elderly (mean +/- SEM, 73 +/- 1 yr) and 12 young (25 +/- 1 yr). The body weight was comparable, 62 +/- 2 kg in the elderly group vs 61 +/- 3 in the young, but the body fat content of the elderly group was significantly greater than that of the young (29 +/- 2% vs 19 +/- 2%, p less than 0.001). The elderly group presented a slight glucose intolerance according to the World Health Organization (WHO) criteria, with a 120-min plasma glucose of 149 +/- 9 mg/dl (p less than 0.005 vs young). The postabsorptive resting energy expenditure (REE) was 0.83 +/- 0.03 kcal/min in the elderly group vs 0.98 +/- 0.04 in the young (p less than 0.02); this decrease of 15% was mainly related to the decrease in fat free mass (FFM) in the elderly group, which averaged 14%. The difference was not significant when REE was expressed per kg FFM. The glucose-induced thermogenesis (GIT) expressed as percent of energy content of the load was 6.2 +/- 0.6% in the elderly group and 8.9 +/- 0.9% in the young (p less than 0.05). It is concluded that the glucose-induced thermogenesis is decreased in elderly subjects. However, when expressed per kg FFM, the increment in energy expenditure (EE), in response to the glucose load, is not different in elderly subjects, suggesting that the decrease of thermogenesis may be attributed to the age-related decrease in FFM.
为研究年龄及身体成分变化对摄入75克葡萄糖负荷后能量消耗增加的影响，对24名受试者进行了呼吸交换测量，其中12名老年人（平均±标准误，73±1岁）和12名年轻人（25±1岁）。两组体重相当，老年组为62±2千克，年轻组为61±3千克，但老年组体脂含量显著高于年轻组（29±2%对19±2%，p<0.001）。根据世界卫生组织（WHO）标准，老年组存在轻度葡萄糖不耐受，120分钟时血浆葡萄糖为149±9毫克/分升（与年轻人相比，p<0.005）。老年组吸收后静息能量消耗（REE）为0.83±0.03千卡/分钟，年轻组为0.98±0.04千卡/分钟（p<0.02）；这种15%的下降主要与老年组去脂体重（FFM）下降有关，平均下降14%。当REE按每千克FFM表示时，差异不显著。以负荷能量含量百分比表示的葡萄糖诱导产热（GIT），老年组为6.2±0.6%，年轻组为8.9±0.9%（p<0.05）。结论是老年受试者的葡萄糖诱导产热降低。然而，当按每千克FFM表示时，老年受试者对葡萄糖负荷的能量消耗（EE）增加并无差异，这表明产热降低可能归因于与年龄相关的FFM下降。
