探索儿童期不良经历与癌症发展之间的联系——一项范围综述的见解与干预建议
Exploring the link between adverse childhood experiences and cancer development - insights and intervention recommendations from a scoping review.
作者信息
Karnes Bethany, Hanissian Alise, White Brianna M, Yaun Jason A, Shaban-Nejad Arash, Schwartz David L
机构信息
University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA.
University of Tennessee Health Science Center-Oak Ridge National Laboratory Center for Biomedical Informatics, Department of Pediatrics, University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA.
出版信息
Npj Ment Health Res. 2025 Jun 2;4(1):23. doi: 10.1038/s44184-025-00138-6.
Recent studies suggest links between adverse childhood experiences (ACEs) and elevated cancer risk, though mechanisms remain unclear. A 2021 review by Hu et al. found a dose-dependent increase in cancer risk among adults with at least one ACE. However, individual risk varies by ACE type and cancer type. For instance, childhood abuse or neglect may heighten cancer risk, while home environment ACEs may not. Potential mechanisms include risky behaviors (e.g., smoking, alcohol use), altered healthcare engagement (e.g., cancer screenings), and biological pathways (e.g., epigenetic changes). This review highlights current findings, research gaps, and implications for cancer prevention. Comprehensive, trauma-informed strategies promoting Positive Childhood Experiences (PCEs) are crucial for reducing cancer risk linked to ACEs in adulthood.
近期研究表明儿童期不良经历（ACEs）与患癌风险升高之间存在关联，不过其机制仍不清楚。胡等人2021年的一项综述发现，至少经历过一次ACE的成年人患癌风险呈剂量依赖性增加。然而，个体风险因ACE类型和癌症类型而异。例如，童年期受虐待或被忽视可能会增加患癌风险，而家庭环境方面的ACEs可能不会。潜在机制包括危险行为（如吸烟、饮酒）、医疗保健参与度改变（如癌症筛查）以及生物学途径（如表观遗传变化）。本综述强调了当前的研究结果、研究空白以及对癌症预防的启示。促进积极童年经历（PCEs）的全面、有创伤意识的策略对于降低成年期与ACEs相关的癌症风险至关重要。
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