Department of Chemistry, Bioscience, and Environmental Engineering, University of Stavanger, Stavanger, 4036, Norway; Department of Biological Sciences, University of Calgary, Calgary, T2N 1N4, Canada; www.katayaproject.com.
Department of Biological Sciences, University of Calgary, Calgary, T2N 1N4, Canada.
Trends Plant Sci. 2019 Apr;24(4):366-381. doi: 10.1016/j.tplants.2018.12.002. Epub 2019 Jan 22.
Peroxisomes perform essential roles in a range of cellular processes, highlighted by lipid metabolism, reactive species detoxification, and response to a variety of stimuli. The ability of peroxisomes to grow, divide, respond to changing cellular needs, interact with other organelles, and adjust their proteome as required, suggest that, like other organelles, their specialized roles are highly regulated. Similar to most other cellular processes, there is an emerging role for protein phosphorylation to regulate these events. In this review, we establish a knowledge framework of key players that control protein phosphorylation events in the plant peroxisome (i.e., the protein kinases and phosphatases), and highlight a vastly expanded set of (phospho)substrates.
过氧化物酶体在一系列细胞过程中发挥着重要作用，其功能包括脂质代谢、活性物质解毒以及对各种刺激的反应。过氧化物酶体能够生长、分裂、响应细胞需求的变化、与其他细胞器相互作用以及根据需要调整其蛋白质组，这表明，与其他细胞器一样，它们的特殊功能受到高度调控。与大多数其他细胞过程一样，蛋白质磷酸化在调节这些事件中起着重要作用。在这篇综述中，我们建立了一个控制植物过氧化物体（即蛋白激酶和磷酸酶）中蛋白质磷酸化事件的关键因子的知识框架，并强调了一大组（磷酸化）底物。
