Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.
Lab Chip. 2017 Nov 21;17(23):3960-3978. doi: 10.1039/c7lc00627f.
The intrinsic limitations of conventional batch synthesis have hindered its applications in both solving classical problems and exploiting new frontiers. Microfluidic technology offers a new platform for chemical synthesis toward either molecules or materials, which has promoted the progress of diverse fields such as organic chemistry, materials science, and biomedicine. In this review, we focus on the improved performance of microreactors in handling various situations, and outline the trend of microfluidic synthesis (microsynthesis, μSyn) from simple microreactors to integrated microsystems. Examples of synthesizing both chemical compounds and micro/nanomaterials show the flexible applications of this approach. We aim to provide strategic guidance for the rational design, fabrication, and integration of microdevices for synthetic use. We critically evaluate the existing challenges and future opportunities associated with this burgeoning field.
传统批量合成的固有局限性阻碍了其在解决经典问题和开拓新前沿方面的应用。微流控技术为化学合成分子或材料提供了一个新的平台，推动了有机化学、材料科学和生物医药等多个领域的进步。在这篇综述中，我们专注于微反应器在处理各种情况时的性能改进，并概述了从简单微反应器到集成微系统的微流控合成（微合成，μSyn）的趋势。合成化学化合物和微/纳米材料的例子展示了这种方法的灵活应用。我们旨在为合成用途的微器件的合理设计、制造和集成提供战略指导。我们批判性地评估了这个新兴领域所面临的现有挑战和未来机遇。
