糖皮质激素和盐皮质激素受体刺激对任务转换的影响。
Influence of glucocorticoid and mineralocorticoid receptor stimulation on task switching.
机构信息
Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Berlin, Germany.
Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Berlin, Germany.
出版信息
Horm Behav. 2019 Mar;109:18-24. doi: 10.1016/j.yhbeh.2019.01.007. Epub 2019 Feb 1.
The influence of stress on executive functions has been demonstrated in numerous studies and is potentially mediated by the stress-induced cortisol release. Yet, the impact of cortisol on cognitive flexibility and task switching in particular remains equivocal. In this study, we investigated the influence of pharmacological glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) stimulation, two corticosteroid receptor types known to be responsible for cortisol effects on the brain. We conducted two experiments, each with 80 healthy participants (40 women and 40 men), and tested the effect of the unspecific MR/GR agonist hydrocortisone (Experiment I) and the more specific MR agonist fludrocortisone (Experiment II) on switch costs and task rule congruency in a bivalent, cued task switching paradigm. The results did not confirm our hypotheses; we found no significant effects of our manipulations on task switching capacity, although general switching and congruency effects were observed. We discuss the absence of MR/GR-mediated effects and propose alternative mechanisms that could explain stress induced effects on task switching.
压力对执行功能的影响在众多研究中得到了证实，其潜在机制可能是压力引起的皮质醇释放。然而，皮质醇对认知灵活性和任务转换的影响仍然存在争议。在这项研究中，我们调查了药理学糖皮质激素受体（GR）和盐皮质激素受体（MR）刺激的影响，这两种皮质类固醇受体类型被认为是皮质醇对大脑影响的原因。我们进行了两项实验，每项实验都有 80 名健康参与者（40 名女性和 40 名男性），并测试了非特异性 MR/GR 激动剂氢化可的松（实验 I）和更特异性的 MR 激动剂氟氢可的松（实验 II）对双价、提示任务转换范式中的转换成本和任务规则一致性的影响。结果没有证实我们的假设；我们没有发现我们的操作对任务转换能力有显著影响，尽管观察到了一般的转换和一致性效应。我们讨论了 MR/GR 介导的效应缺失，并提出了可以解释应激诱导对任务转换影响的替代机制。
Zotero 插件