Krüger J, Desaga F J
Blut. 1978 Jun 20;36(6):315-23. doi: 10.1007/BF01000587.
As part of an overall assessment of immunological function, several aspects of cellular immunity and circulating lymphocyte subpopulations were evaluated in a group of 10 patients with idiopathic autoimmunhemolytic anemia (AIHA). The absolute numbers of circulating T and B cells were reduced in the patient group compared to normals. A shift from "corticosteroid-sensitive" to "corticosteroid-resistent" and activated cells in the cytogram of clustered Fe-(III)-hydroxide-glucane saccharose labeled T lymphocytes was apparent. In vitro studies of cellular reactivity, as evaluated by PHA, ConA, PWM, antigens and allogeneic cell induced proliferation showed a blend of general or selective depression and sometimes a normal or increased activity with no definite correlation with both the number of circulating T cells and the extent of the hemolytic activity by the disease. The possible significance of the findings is discussed.
作为免疫功能全面评估的一部分，对一组10例特发性自身免疫性溶血性贫血（AIHA）患者的细胞免疫和循环淋巴细胞亚群的几个方面进行了评估。与正常人相比，患者组循环T细胞和B细胞的绝对数量减少。在聚集的氢氧化铁（III）-葡聚糖蔗糖标记的T淋巴细胞的细胞图中，从“皮质类固醇敏感”细胞向“皮质类固醇抵抗”和活化细胞的转变很明显。通过PHA、ConA、PWM、抗原和同种异体细胞诱导的增殖评估的细胞反应性的体外研究显示，存在普遍或选择性抑制，有时活性正常或增加，与循环T细胞数量和疾病溶血活性程度均无明确相关性。讨论了这些发现的可能意义。
