Kennedy Krieger Institute, Center for Child and Family Traumatic Stress, 1741 Ashland Avenue, Baltimore, MD 21205, United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Neurobiol Dis. 2019 Nov;131:104378. doi: 10.1016/j.nbd.2019.01.015. Epub 2019 Jan 24.
This paper reviews the literature on the association between experiences of child abuse and neglect and the development of psychoses. It then explores the premise that psychotic patients with a history of maltreatment may comprise a clinically and biological distinct subgroup. The review demonstrates that there is a growing consensus in the field that experiences of child maltreatment contribute to the onset of psychotic symptoms and psychotic disorders. There is also strong support for the premise that patients with psychotic disorders and histories of child maltreatment have distinct clinical characteristics and unique treatment needs, and emerging preliminary data to suggest psychotic patients with a history of maltreatment may comprise a distinct neurobiological subgroup. The mechanisms by which experiences of child maltreatment confers risk for psychotic disorders remains unknown, and the review highlights the value of incorporating translational research perspectives to advance knowledge in this area.
这篇论文回顾了有关儿童期虐待和忽视经历与精神病发展之间关联的文献。然后探讨了这样一个前提，即有虐待史的精神病患者可能构成临床上和生物学上明显不同的亚组。综述表明，该领域越来越达成共识，即儿童期虐待经历会导致精神病症状和精神病障碍的发作。也有力支持这样一个前提，即有精神病障碍和儿童期虐待史的患者具有明显不同的临床特征和独特的治疗需求，而且初步数据表明，有虐待史的精神病患者可能构成一个独特的神经生物学亚组。儿童期虐待经历导致精神病障碍的风险的机制尚不清楚，该综述强调了纳入转化研究观点以促进该领域知识发展的价值。
