越南北部伯克霍尔德菌分离株的药敏情况。
Antimicrobial susceptibility of Burkholderia pseudomallei isolates in Northern Vietnam.
机构信息
Hanoi Medical University, Hanoi, Vietnam; Bach Mai Hospital, Hanoi, Vietnam.
Hanoi Medical University, Hanoi, Vietnam.
出版信息
J Glob Antimicrob Resist. 2019 Sep;18:34-36. doi: 10.1016/j.jgar.2019.01.024. Epub 2019 Jan 24.
OBJECTIVES
The antimicrobial susceptibility pattern of clinical Burkholderia pseudomallei (B. pseudomallei) in Vietnam has not been reported since the first publication in 2008. The present study aimed to determine the antimicrobial susceptibility pattern of B. pseudomallei isolated in a tertiary referral centre in Hanoi from January 2012 to December 2017.
METHODS
A total of 312 B. pseudomallei isolates obtained from melioidosis patients admitted to a 2000-bed general hospital were analysed by the Etest method. Interpretation of the susceptibility testing results were reported using Clinical and Laboratory Standards Institute guidelines.
RESULTS
All isolates were susceptible to ceftazidime, imipenem and amoxicillin-clavulanate (100%) with MIC relatively low (2μg/mL). Two isolates had intermediate resistance to doxycycline (0.6%) and 34 isolates were resistant to trimethoprim/sulfamethoxazole (10.9%).
CONCLUSION
The results of this study suggest that currently recommended antibiotics for melioidosis treatment can be empirically used, but continuously monitoring antimicrobial susceptibility should be a concern.
目的
自 2008 年首次发表以来，尚未有报道显示越南临床类鼻疽伯克霍尔德菌（B. pseudomallei）的药敏模式。本研究旨在确定 2012 年 1 月至 2017 年 12 月期间在河内一家三级转诊中心分离的 B. pseudomallei 的药敏模式。
方法
采用 Etest 法对从一家 2000 张床位的综合医院收治的类鼻疽病患者中获得的 312 株 B. pseudomallei 分离株进行分析。药敏试验结果的解释按照临床和实验室标准协会的指南进行报告。
结果
所有分离株对头孢他啶、亚胺培南和阿莫西林克拉维酸（100%）均敏感，MIC 相对较低（2μg/mL）。有 2 株对强力霉素（0.6%）表现出中介耐药性，有 34 株对复方磺胺甲噁唑（10.9%）耐药。
结论
本研究结果表明，目前推荐用于治疗类鼻疽的抗生素可以经验性使用，但应持续监测抗菌药物敏感性。
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