在两项病例对照研究的二次分析中，供体特征不影响输血相关急性肺损伤的发生率。

Donor characteristics do not influence transfusion-related acute lung injury incidence in a secondary analysis of two case-control studies.

作者信息

Peters A L, van de Weerdt E K, Prinsze F, de Korte D, Juffermans N P, Vlaar A P J

机构信息

Laboratory of Experimental Intensive Care and Anesthesia, Academic Medical Center, Amsterdam, The Netherlands; Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands; Department Product and Process Development, Sanquin Blood Supply, Amsterdam, The Netherlands.

出版信息

Transfus Clin Biol. 2019 Feb;26(1):10-17. doi: 10.1016/j.tracli.2018.05.003. Epub 2018 Jul 4.

DOI:10.1016/j.tracli.2018.05.003

PMID:30686333

Abstract

OBJECTIVE

To investigate the relation between donor characteristics and TRALI incidence.

BACKGROUND

Transfusion-related acute lung injury (TRALI) is a potentially fatal complication of transfusion. In pre-clinical studies and several clinical studies, TRALI has been related to loss of product quality during red blood cell (RBC) storage, called the "storage lesion". Donor characteristics, as for example age, genetics and life style choices influence this "storage lesion". We hypothesized that donor sex, age and blood type is related to TRALI incidence.

METHODS/MATERIALS: We performed a secondary analysis of two cohort studies, designed to identify TRALI risk factors by matching TRALI patients to transfused controls. We obtained donor sex, age and blood type from the Dutch Blood Bank Sanquin and investigated TRALI incidence in patients who were exposed to a certain donor characteristic. We used Kruskal-Wallis testing to compare the number of transfused products and Chi testing to compare proportions of TRALI patients and transfused control.

RESULTS

After implementation of the male-donor only plasma strategy, patients received more transfusion products from male donors. However, we did not detect a relation between TRALI incidence and donor sex. Both TRALI patients and transfused controls received mainly products from donors over 41 years old, but donor age did not influence TRALI risk. Donor blood type, the transfusion of blood type-compatible and blood type-matched products also had no influence on TRALI incidence.

CONCLUSION

We conclude that in two cohorts of TRALI patients, donor age, donor sex and donor blood type are unrelated to TRALI.

摘要

目的

研究献血者特征与输血相关急性肺损伤（TRALI）发生率之间的关系。

背景

输血相关急性肺损伤是一种潜在致命的输血并发症。在临床前研究和多项临床研究中，TRALI与红细胞（RBC）储存期间产品质量的下降有关，即所谓的“储存损伤”。献血者特征，如年龄、遗传和生活方式选择会影响这种“储存损伤”。我们假设献血者性别、年龄和血型与TRALI发生率有关。

方法/材料：我们对两项队列研究进行了二次分析，旨在通过将TRALI患者与输血对照进行匹配来确定TRALI的危险因素。我们从荷兰血库Sanquin获取了献血者的性别、年龄和血型，并调查了暴露于特定献血者特征的患者中的TRALI发生率。我们使用Kruskal-Wallis检验来比较输血产品的数量，并使用卡方检验来比较TRALI患者和输血对照的比例。

结果

在实施仅使用男性献血者血浆的策略后，患者从男性献血者那里接受了更多的输血产品。然而，我们未检测到TRALI发生率与献血者性别之间的关系。TRALI患者和输血对照主要都接受了41岁以上献血者的产品，但献血者年龄并未影响TRALI风险。献血者血型、输注血型相容和血型匹配的产品对TRALI发生率也没有影响。