Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany.
Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany.
J Neuroimmunol. 2019 Feb 15;327:10-14. doi: 10.1016/j.jneuroim.2019.01.005. Epub 2019 Jan 11.
In Myasthenia Gravis (MG) thymic pathologies are often present and thymectomy is used as treatment. By flow cytometry we elucidated alterations of naïve CD4 T cell homeostasis in MG patients and patients with thymoma. MG patients showed increased absolute numbers of CD31naïve CD4 T cells. Thymoma patients displayed a significantly higher fraction of peripheral blood CD31naive T cells. We show an altered naive CD4 T cell homeostasis in MG patients that might predispose to autoimmunity. Aberrant generation of T cells in thymoma can be detected by an increased frequency of CD31naive CD4 T cells in the periphery.
在重症肌无力（MG）中，胸腺病理学常常存在，胸腺切除术被用作治疗方法。通过流式细胞术，我们阐明了 MG 患者和胸腺瘤患者中幼稚 CD4 T 细胞稳态的改变。MG 患者表现出 CD31naive CD4 T 细胞绝对数量的增加。胸腺瘤患者显示外周血 CD31naive T 细胞的比例明显更高。我们显示 MG 患者中幼稚 CD4 T 细胞稳态发生改变，这可能使自身免疫易感性增加。通过外周血中 CD31naive CD4 T 细胞频率的增加，可以检测到胸腺瘤中 T 细胞的异常产生。
