Schmidt S, Padberg F
Department of Neurology, University of Bonn (Rheinische Friedrich Wilhelms-Universität), Germany.
J Neurol Sci. 1998 May 7;157(2):201-5. doi: 10.1016/s0022-510x(98)00085-9.
The most common autoimmune disease associated with thymoma is myasthenia gravis. In addition, cellular and humoral immune defects have been frequently reported in association with thymic neoplasms. Here we report the case of a patient with myasthenia gravis receiving long-term immunosuppression with azathioprine and recurrent well-differentiated thymic carcinoma who developed CD4+ T-cell depletion and CNS cryptococcosis after multiple courses of chemotherapy and mediastinal irradiation. We hypothesize that in thymectomized patients bone marrow suppression and abrogation of the peripheral T-cell pool can result in a delayed T-cell regeneration due to the lack of functional thymic epithelium.
与胸腺瘤相关的最常见自身免疫性疾病是重症肌无力。此外，细胞免疫和体液免疫缺陷也经常被报道与胸腺肿瘤有关。在此，我们报告一例接受硫唑嘌呤长期免疫抑制治疗的重症肌无力患者，其复发了高分化胸腺癌，在多疗程化疗和纵隔放疗后出现了CD4+ T细胞耗竭和中枢神经系统隐球菌病。我们推测，在胸腺切除的患者中，骨髓抑制和外周T细胞池的消除可能由于缺乏功能性胸腺上皮而导致T细胞再生延迟。
