Vreeke Shawna, Korzun Tetiana, Luo Wentai, Jensen R Paul, Peyton David H, Strongin Robert M
Department of Chemistry, Portland State University, Portland, Oregon, USA.
Department of Civil and Environmental Engineering, Portland State University, Portland, Oregon, USA.
Aerosol Sci Technol. 2018;52(4):370-376. doi: 10.1080/02786826.2018.1424316. Epub 2018 Jan 23.
Recently, we reported the presence of dihydroxyacetone (DHA), the active ingredient in sunless tanners, in the aerosol of an electronic cigarette. DHA has been shown to react with DNA . The FDA restricts the use of DHA to external application only. It states that it should not be inhaled, ingested, or come into contact with any areas containing mucous membranes, due to unknown risk. Herein, the quantification of DHA in the aerosols of three brands of e-cigarettes has been carried out. These included two devices with horizontal heating coil configurations as well as one with a sub-ohm resistance vertical heating coil. In order to understand and begin to address the origin of DHA and related aerosol products, the wicking properties of the three e-cigarettes were compared. DHA levels were analyzed by a combination of GS/MS and H NMR. DHA was found in all three e-cigarettes, with substantially less in the sub-ohm, vertical coil device as compared to the horizontal coil devices (e.g., 0.088 g/puff vs. 2.29 g/puff, respectively). Correspondingly, the temperature of the wet layer of the wick for the vertical coil was relatively stable, compared to the wicks for the horizontal coils, upon increasing battery power output. This result is in agreement with prior studies of e-cigarette wicking efficiency and aerosol toxin formation. The temperature measurements reported are a simple means for comparing devices with different design properties during operation.
最近，我们报告了电子烟气溶胶中存在二羟基丙酮（DHA），即免晒古铜色产品中的活性成分。DHA已被证明会与DNA发生反应。美国食品药品监督管理局（FDA）将DHA的使用限制为仅可外用。它指出，由于存在未知风险，不应吸入、摄入或使其接触任何含有黏膜的区域。在此，我们对三个品牌电子烟的气溶胶中的DHA进行了定量分析。这些电子烟包括两款采用水平加热线圈配置的设备以及一款采用低电阻垂直加热线圈的设备。为了了解并着手探究DHA及相关气溶胶产品的来源，我们比较了这三款电子烟的导液性能。通过气相色谱/质谱联用（GS/MS）和核磁共振氢谱（H NMR）相结合的方法对DHA含量进行了分析。在所有三款电子烟中均检测到了DHA，与水平线圈设备相比，低电阻垂直线圈设备中的DHA含量要少得多（例如，分别为0.088微克/口与2.29微克/口）。相应地，在增加电池输出功率时，与水平线圈的导液芯相比，垂直线圈导液芯湿层的温度相对稳定。这一结果与之前关于电子烟导液效率和气溶胶毒素形成的研究结果一致。所报告的温度测量是在操作过程中比较具有不同设计特性的设备的一种简单方法。
