Pulgar Victor M
Department of Pharmaceutical Sciences, Campbell University, Buies Creek, NC, United States.
Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Front Neurosci. 2019 Jan 11;12:1019. doi: 10.3389/fnins.2018.01019. eCollection 2018.
The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into the brain. Several strategies aim to overcome this obstacle and promote efficient and specific crossing through BBB of therapeutically relevant agents. One of those strategies uses the physiological process of receptor-mediated transcytosis (RMT) to transport cargo through the brain endothelial cells toward brain parenchyma. Recent developments in our understanding of intracellular trafficking and receptor binding as well as in protein engineering and nanotechnology have potentiated the opportunities for treatment of CNS diseases using RMT. In this mini-review, the current understanding of BBB structure is discussed, and recent findings exemplifying critical advances in RMT-mediated brain drug delivery are briefly presented.
血脑屏障（BBB）对药物进入大脑构成了巨大挑战。有几种策略旨在克服这一障碍，并促进治疗相关药物高效、特异性地穿过血脑屏障。其中一种策略利用受体介导的转胞吞作用（RMT）的生理过程，将货物通过脑内皮细胞转运至脑实质。我们对细胞内运输和受体结合以及蛋白质工程和纳米技术的理解取得的最新进展，增加了利用RMT治疗中枢神经系统疾病的机会。在本综述中，我们讨论了对血脑屏障结构的当前理解，并简要介绍了RMT介导的脑药物递送方面关键进展的最新发现。
