Staurengo-Ferrari Larissa, Badaro-Garcia Stephanie, Hohmann Miriam S N, Manchope Marília F, Zaninelli Tiago H, Casagrande Rubia, Verri Waldiceu A
Departamento de Patologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.
Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Estadual de Londrina, Londrina, Brazil.
Front Pharmacol. 2019 Jan 11;9:1536. doi: 10.3389/fphar.2018.01536. eCollection 2018.
Despite the progress that has occurred in recent years in the development of therapies to treat painful and inflammatory diseases, there is still a need for effective and potent analgesics and anti-inflammatory drugs. It has long been known that several types of antioxidants also possess analgesic and anti-inflammatory properties, indicating a strong relationship between inflammation and oxidative stress. Understanding the underlying mechanisms of action of anti-inflammatory and analgesic drugs, as well as essential targets in disease physiopathology, is essential to the development of novel therapeutic strategies. The Nuclear factor-2 erythroid related factor-2 (Nrf2) is a transcription factor that regulates cellular redox status through endogenous antioxidant systems with simultaneous anti-inflammatory activity. This review summarizes the molecular mechanisms and pharmacological actions screened that link analgesic, anti-inflammatory, natural products, and other therapies to Nrf2 as a regulatory system based on emerging evidences from experimental disease models and new clinical trial data.
尽管近年来在治疗疼痛和炎症性疾病的疗法开发方面取得了进展，但仍需要有效且强效的镇痛药和抗炎药。长期以来，人们已知几种类型的抗氧化剂也具有镇痛和抗炎特性，这表明炎症与氧化应激之间存在密切关系。了解抗炎和镇痛药的潜在作用机制以及疾病病理生理学中的关键靶点，对于开发新的治疗策略至关重要。核因子2红细胞相关因子2（Nrf2）是一种转录因子，它通过具有同时抗炎活性的内源性抗氧化系统调节细胞氧化还原状态。本综述基于实验性疾病模型的新证据和新的临床试验数据，总结了将镇痛、抗炎、天然产物及其他疗法与作为调节系统的Nrf2联系起来的分子机制和药理学作用。
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