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Rm01的群体感应系统控制脂肪酶和生物膜的形成。

Quorum Sensing System of Rm01 Controls Lipase and Biofilm Formation.

作者信息

Su Ying, Tang Kaihao, Liu Jiwen, Wang Yan, Zheng Yanfen, Zhang Xiao-Hua

机构信息

College of Marine Life Science, Ocean University of China, Qingdao, China.

Weifang Engineering Vocational College, Weifang, China.

出版信息

Front Microbiol. 2019 Jan 9;9:3304. doi: 10.3389/fmicb.2018.03304. eCollection 2018.

DOI:10.3389/fmicb.2018.03304
PMID:30687283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6333666/
Abstract

Quorum sensing (QS) promotes extracellular enzyme (EE) activity via the exogenous signal -acylhomoserine lactone (AHL), which facilitates marine particle degradation, but the species that engage in this regulatory mechanism remain unclear. Here, we obtained AHL-producing and AHL-degrading strains from marine particles. The strain Rm01 of the group (RBG), which was capable of both AHL producing and degrading, was chosen to represent these strains. We demonstrated that Rm01 possessed a complex QS network comprising AHL-based QS and quorum quenching (QQ) systems and autoinducer-2 (AI-2) perception system. Rm01 was able to respond to multiple exogenous QS signals through the QS network. By applying self-generated AHLs and non-self-generated AHLs and AI-2 QS signal molecules, we modulated biofilm formation and lipase production in Rm01, which reflected the coordination of bacterial metabolism with that of other species via eavesdropping on exogenous QS signals. These results suggest that might be one of the participators that could regulate EE activities by responding to QS signals in marine particles.

摘要

群体感应（QS）通过外源性信号——酰基高丝氨酸内酯（AHL）促进细胞外酶（EE）活性，这有助于海洋颗粒的降解，但参与这种调节机制的物种仍不清楚。在这里，我们从海洋颗粒中获得了产生AHL和降解AHL的菌株。选择能够同时产生和降解AHL的玫瑰杆菌群（RBG）的Rm01菌株来代表这些菌株。我们证明Rm01拥有一个复杂的群体感应网络，包括基于AHL的群体感应和群体淬灭（QQ）系统以及自诱导物-2（AI-2）感知系统。Rm01能够通过群体感应网络对多种外源性群体感应信号作出反应。通过应用自身产生的AHL和非自身产生的AHL以及AI-2群体感应信号分子，我们调节了Rm01中的生物膜形成和脂肪酶产生，这反映了细菌代谢与其他物种代谢通过窃听外源性群体感应信号的协调。这些结果表明，Rm01可能是通过响应海洋颗粒中的群体感应信号来调节细胞外酶活性的参与者之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/eaf0db145be8/fmicb-09-03304-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/8fe0754ab136/fmicb-09-03304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/43c01a9b2012/fmicb-09-03304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/06b06f8f927e/fmicb-09-03304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/b8b9b2a3471c/fmicb-09-03304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/eaf0db145be8/fmicb-09-03304-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/8fe0754ab136/fmicb-09-03304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/43c01a9b2012/fmicb-09-03304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/06b06f8f927e/fmicb-09-03304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/b8b9b2a3471c/fmicb-09-03304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406a/6333666/eaf0db145be8/fmicb-09-03304-g005.jpg

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