Department of Microbiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Immunol. 2019 Jan 9;9:3096. doi: 10.3389/fimmu.2018.03096. eCollection 2018.
B-cell activation plays a crucial part in the immune system and is initiated via interaction between the B cell receptor (BCR) and specific antigens. In recent years with the help of modern imaging techniques, it was found that the cortical actin cytoskeleton changes dramatically during B-cell activation. In this review, we discuss how actin-cytoskeleton reorganization regulates BCR signaling in different stages of B-cell activation, specifically when stimulated by antigens, and also how this reorganization is mediated by BCR signaling molecules. Abnormal BCR signaling is associated with the progression of lymphoma and immunological diseases including autoimmune disorders, and recent studies have proved that impaired actin cytoskeleton can devastate the normal activation of B cells. Therefore, to figure out the coordination between the actin cytoskeleton and BCR signaling may reveal an underlying mechanism of B-cell activation, which has potential for new treatments for B-cell associated diseases.
B 细胞激活在免疫系统中起着至关重要的作用，它是通过 B 细胞受体 (BCR) 与特定抗原之间的相互作用而启动的。近年来，借助现代成像技术，人们发现 B 细胞激活过程中皮质肌动蛋白细胞骨架会发生剧烈变化。在这篇综述中，我们讨论了肌动蛋白细胞骨架重组如何在 B 细胞激活的不同阶段（特别是在受到抗原刺激时）调节 BCR 信号转导，以及这种重组是如何通过 BCR 信号转导分子介导的。BCR 信号异常与淋巴瘤和免疫性疾病（包括自身免疫性疾病）的进展有关，最近的研究证明，肌动蛋白细胞骨架受损会破坏 B 细胞的正常激活。因此，阐明肌动蛋白细胞骨架与 BCR 信号之间的协调关系可能揭示 B 细胞激活的潜在机制，为 B 细胞相关疾病的治疗提供新的思路。
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