Cancer Research UK London Research Institute, United Kingdom.
Annu Rev Immunol. 2010;28:185-210. doi: 10.1146/annurev-immunol-030409-101216.
B cell activation is initiated by the ligation of the B cell receptor (BCR) with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here we review recent literature concerned with the spatiotemporal dynamic characterization of the early molecular events of B cell activation, including the initiation of BCR triggering, the formation of BCR microclusters, and the dynamic regulation of BCR signaling. Because these events involve the considerable reorganization of molecules within the membrane, an important role for the cytoskeleton is emerging in the regulation of B cell activation. At each stage we highlight the role of the cytoskeleton, establishing its pivotal position during the initiation and regulation of B cell activation.
B 细胞的激活是由 B 细胞受体（BCR）与抗原的结合所启动的，最终导致产生针对潜在致病入侵物的保护性抗体。在这里，我们回顾了最近有关 B 细胞激活早期分子事件的时空动态特征的文献，包括 BCR 触发的启动、BCR 微簇的形成以及 BCR 信号的动态调节。由于这些事件涉及膜内分子的大量重排，细胞骨架在 B 细胞激活的调节中起着重要作用。在每个阶段，我们都强调了细胞骨架的作用，确立了它在 B 细胞激活的启动和调节中的关键地位。
